Torquetenovirus (TTV) is the most abundant component of human virome. Virologists have long ignored this orphan and highly divergent virus, in part because TTV cannot be cultured and because it lacks serology reagents and animal models. Nevertheless, it is almost endemic worldwide and is insensitive to current antiviral drugs, so its monitoring is useful in various conditions. To date, TTV as a marker has proved useful in at least two circumstances: to identify anthropogenic pollution and to assess functional immune competence in immunosuppressed individuals. This review summarizes recent findings about TTV and discusses the main hurdles in translating them into clinical diagnostics.

Torquetenovirus: the human virome from bench to bedside / Focosi, D; Antonelli, Guido; Pistello, M; Maggi, F.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - STAMPA. - 22:7(2016), pp. 589-593. [10.1016/j.cmi.2016.04.007]

Torquetenovirus: the human virome from bench to bedside

ANTONELLI, Guido;
2016

Abstract

Torquetenovirus (TTV) is the most abundant component of human virome. Virologists have long ignored this orphan and highly divergent virus, in part because TTV cannot be cultured and because it lacks serology reagents and animal models. Nevertheless, it is almost endemic worldwide and is insensitive to current antiviral drugs, so its monitoring is useful in various conditions. To date, TTV as a marker has proved useful in at least two circumstances: to identify anthropogenic pollution and to assess functional immune competence in immunosuppressed individuals. This review summarizes recent findings about TTV and discusses the main hurdles in translating them into clinical diagnostics.
2016
Maintenance immunosuppression; Opportunistic infections; Solid organ transplantation; TTV; Virome
01 Pubblicazione su rivista::01a Articolo in rivista
Torquetenovirus: the human virome from bench to bedside / Focosi, D; Antonelli, Guido; Pistello, M; Maggi, F.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - STAMPA. - 22:7(2016), pp. 589-593. [10.1016/j.cmi.2016.04.007]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/878568
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 91
  • Scopus 171
  • ???jsp.display-item.citation.isi??? 159
social impact