Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and to which extent they affect common cellular pathways remains incompletely understood. To address these questions, we performed an interactomic analysis to identify binding partners of wild-type (WT) and ALS-associated mutant versions of ATXN2, C9orf72, FUS, OPTN, TDP-43 and UBQLN2 in neuronal cells. This analysis identified several known but also many novel binding partners of these proteins.

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways / Blokhuis, Anna M.; Koppers, Max; Groen, Ewout J. N.; van Den Heuvel, Dianne M. A.; DINI MODIGLIANI, Stefano; Anink, Jasper J.; Fumoto, Katsumi; van Diggelen, Femke; Snelting, Anne; Sodaar, Peter; Verheijen, Bert M.; Demmers, Jeroen A. A.; Veldink, Jan H.; Aronica, Eleonora; Bozzoni, Irene; Den Hertog, Jeroen; van Den Berg, Leonard H.; Pasterkamp, R. Jeroen. - In: ACTA NEUROPATHOLOGICA. - ISSN 0001-6322. - 132:2(2016), pp. 175-196. [10.1007/s00401-016-1575-8]

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

DINI MODIGLIANI, STEFANO;BOZZONI, Irene;
2016

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and to which extent they affect common cellular pathways remains incompletely understood. To address these questions, we performed an interactomic analysis to identify binding partners of wild-type (WT) and ALS-associated mutant versions of ATXN2, C9orf72, FUS, OPTN, TDP-43 and UBQLN2 in neuronal cells. This analysis identified several known but also many novel binding partners of these proteins.
2016
Amyotrophic lateral sclerosis; C9orf72; FMRP; FUS; Motor neuron; TDP-43; Neurology (clinical); 2734; Cellular and Molecular Neuroscience
01 Pubblicazione su rivista::01a Articolo in rivista
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways / Blokhuis, Anna M.; Koppers, Max; Groen, Ewout J. N.; van Den Heuvel, Dianne M. A.; DINI MODIGLIANI, Stefano; Anink, Jasper J.; Fumoto, Katsumi; van Diggelen, Femke; Snelting, Anne; Sodaar, Peter; Verheijen, Bert M.; Demmers, Jeroen A. A.; Veldink, Jan H.; Aronica, Eleonora; Bozzoni, Irene; Den Hertog, Jeroen; van Den Berg, Leonard H.; Pasterkamp, R. Jeroen. - In: ACTA NEUROPATHOLOGICA. - ISSN 0001-6322. - 132:2(2016), pp. 175-196. [10.1007/s00401-016-1575-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/877036
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