Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and to which extent they affect common cellular pathways remains incompletely understood. To address these questions, we performed an interactomic analysis to identify binding partners of wild-type (WT) and ALS-associated mutant versions of ATXN2, C9orf72, FUS, OPTN, TDP-43 and UBQLN2 in neuronal cells. This analysis identified several known but also many novel binding partners of these proteins.
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways / Blokhuis, Anna M.; Koppers, Max; Groen, Ewout J. N.; van Den Heuvel, Dianne M. A.; DINI MODIGLIANI, Stefano; Anink, Jasper J.; Fumoto, Katsumi; van Diggelen, Femke; Snelting, Anne; Sodaar, Peter; Verheijen, Bert M.; Demmers, Jeroen A. A.; Veldink, Jan H.; Aronica, Eleonora; Bozzoni, Irene; Den Hertog, Jeroen; van Den Berg, Leonard H.; Pasterkamp, R. Jeroen. - In: ACTA NEUROPATHOLOGICA. - ISSN 0001-6322. - 132:2(2016), pp. 175-196. [10.1007/s00401-016-1575-8]
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways
DINI MODIGLIANI, STEFANO;BOZZONI, Irene;
2016
Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and to which extent they affect common cellular pathways remains incompletely understood. To address these questions, we performed an interactomic analysis to identify binding partners of wild-type (WT) and ALS-associated mutant versions of ATXN2, C9orf72, FUS, OPTN, TDP-43 and UBQLN2 in neuronal cells. This analysis identified several known but also many novel binding partners of these proteins.| File | Dimensione | Formato | |
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Blokhuis_Comparative_2016
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