The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investigate the role of the MEK/ERK pathway in controlling the cancer stem-like phenotype using a model of rhabdospheres derived from the embryonal rhabdomyosarcoma cell line (RD).
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population / Ciccarelli, Carmela; Vulcano, Francesca; Milazzo, Luisa; Gravina, GIOVANNI LUCA; Marampon, Francesco; Macioce, Giampiero; Giampaolo, Adele; Tombolini, Vincenzo; DI PAOLO, Virginia; Hassan, Hamisa Jane; Zani, Bianca Maria. - In: MOLECULAR CANCER. - ISSN 1476-4598. - ELETTRONICO. - 15:(2016). [10.1186/s12943-016-0501-y]
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
GRAVINA, GIOVANNI LUCA;Marampon, Francesco;TOMBOLINI, Vincenzo;DI PAOLO, VIRGINIA;ZANI, Bianca Maria
2016
Abstract
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investigate the role of the MEK/ERK pathway in controlling the cancer stem-like phenotype using a model of rhabdospheres derived from the embryonal rhabdomyosarcoma cell line (RD).| File | Dimensione | Formato | |
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