Two new beta-adrenergic receptor agonist drugs illegally used as growth promoters in animal production, found in feeding stuffs are described. Beta(1)- and beta(2)-adrenergic activity was evaluated on isolated guinea-pig atrium and trachea in comparison with clenbuterol. In isolated trachea the compounds showed myorelaxant potency lower than clenbuterol, on the contrary, in the guinea-pig atrium (heart-beat rate stimulant effect) the compounds were more potent than clenbuterol.
NEW BETA-ADRENERGIC AGONISTS USED ILLICITLY AS GROWTH PROMOTERS IN ANIMAL BREEDING: CHEMICAL AND PHARMACODYNAMIC STUDIES / Mazzanti, Gabriela; Daniele, Claudia; G., Boatto; G., Manca; G., Brambilla; A., Loizzo. - In: TOXICOLOGY. - ISSN 0300-483X. - STAMPA. - 187:(2003), pp. 91-99. [10.1016/S0300-483X(03)00059-3]
NEW BETA-ADRENERGIC AGONISTS USED ILLICITLY AS GROWTH PROMOTERS IN ANIMAL BREEDING: CHEMICAL AND PHARMACODYNAMIC STUDIES
MAZZANTI, Gabriela;DANIELE, Claudia;
2003
Abstract
Two new beta-adrenergic receptor agonist drugs illegally used as growth promoters in animal production, found in feeding stuffs are described. Beta(1)- and beta(2)-adrenergic activity was evaluated on isolated guinea-pig atrium and trachea in comparison with clenbuterol. In isolated trachea the compounds showed myorelaxant potency lower than clenbuterol, on the contrary, in the guinea-pig atrium (heart-beat rate stimulant effect) the compounds were more potent than clenbuterol.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
