In recent years, several studies have demonstrated the strong cytotoxicity toward bacteria of graphene-based materials, suggesting their use as antimicrobial agents. The objective of this study was to evaluate the antibacterial activity against Streptococcus mutans, the principal microbiological agent in the etiology of dental caries, of two types of graphene nanoplatelets (GNPs), characterized by different thickness and lateral dimensions of the flakes. The antimicrobial properties of GNPs were valued on some plaque and saliva samples extracted from children with dental caries. Our results show that the killing effect of GNPs on S. mutans cells is both lateral size and thickness dependent. In fact, lower thickness and smaller size GNPs exhibit stronger antibacterial activity than larger and thicker ones. Scanning electron microscopy analysis revealed that GNPs interact strongly with cells. This study suggests that GNPs may be highly effective against S. mutans and therefore caries.

Antimicrobial activity of graphene nanoplatelets against Streptococcus mutans / Rago, I.; Bregnocchi, A.; Zanni, E.; D’Aloia, A. G.; De Angelis, F.; Bossu, M.; De Bellis, G.; Polimeni, A.; Uccelletti, D.; Sarto, M. S.. - ELETTRONICO. - (2015), pp. 9-12. ((Intervento presentato al convegno 15th IEEE international conference on nanotechnology tenutosi a Rome, Italy nel 27-30 July 2015 [10.1109/NANO.2015.7388945].

Antimicrobial activity of graphene nanoplatelets against Streptococcus mutans

I. Rago
Primo
;
A. Bregnocchi
Secondo
;
A. G. D’Aloia;F. De Angelis;M. Bossu;G. De Bellis;A. Polimeni;D. Uccelletti
Penultimo
;
M. S. Sarto
Ultimo
2015

Abstract

In recent years, several studies have demonstrated the strong cytotoxicity toward bacteria of graphene-based materials, suggesting their use as antimicrobial agents. The objective of this study was to evaluate the antibacterial activity against Streptococcus mutans, the principal microbiological agent in the etiology of dental caries, of two types of graphene nanoplatelets (GNPs), characterized by different thickness and lateral dimensions of the flakes. The antimicrobial properties of GNPs were valued on some plaque and saliva samples extracted from children with dental caries. Our results show that the killing effect of GNPs on S. mutans cells is both lateral size and thickness dependent. In fact, lower thickness and smaller size GNPs exhibit stronger antibacterial activity than larger and thicker ones. Scanning electron microscopy analysis revealed that GNPs interact strongly with cells. This study suggests that GNPs may be highly effective against S. mutans and therefore caries.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/871857
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