Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.

Alternative splicing tends to avoid partial removals of protein-protein interaction sites / Colantoni, Alessio; Bianchi, Valerio; Gherardini, Pier Federico; SCALIA TOMBA, Gianpaolo; Ausiello, Gabriele; Helmer Citterich, Manuela; Ferre', Fabrizio. - In: BMC GENOMICS. - ISSN 1471-2164. - ELETTRONICO. - 14:(2013), p. 379. [10.1186/1471-2164-14-379]

Alternative splicing tends to avoid partial removals of protein-protein interaction sites

COLANTONI, ALESSIO
Primo
;
SCALIA TOMBA, Gianpaolo;AUSIELLO, Gabriele;FERRE', FABRIZIO
Ultimo
2013

Abstract

Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.
2013
Alternative splicing; disordered regions; hot spots; protein three-dimensional structure; protein-protein interaction; binding sites; cullin proteins; DNA-binding proteins; humans; modelsmolecular; protein binding; protein isoforms; protein multimerization; protein structure, quaternary; proteins; thermodynamics; alternative splicing; proteomics; biotechnology; genetics
01 Pubblicazione su rivista::01a Articolo in rivista
Alternative splicing tends to avoid partial removals of protein-protein interaction sites / Colantoni, Alessio; Bianchi, Valerio; Gherardini, Pier Federico; SCALIA TOMBA, Gianpaolo; Ausiello, Gabriele; Helmer Citterich, Manuela; Ferre', Fabrizio. - In: BMC GENOMICS. - ISSN 1471-2164. - ELETTRONICO. - 14:(2013), p. 379. [10.1186/1471-2164-14-379]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/871017
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