Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and mediate the greater risk of relapse are poorly understood and knowledge of risk factors is to date extremely limited. In this study, we modeled childhood maltreatment by exposing juvenile mice to a threatening social experience (social stressed, S-S). We showed that S-S experience influenced the propensity to reinstate cocaineseeking after periods of withdrawal in adulthood. By exploring global gene expression in blood leukocytes we found that this behavioral phenotype was associated with greater blood coagulation. In parallel, impairments in brain microvasculature were observed in S-S mice. Furthermore, treatment with an anticoagulant agent during withdrawal abolished the susceptibility to reinstate cocaine-seeking in S-S mice. These findings provide novel insights into a possible molecular mechanism by which childhood maltreatment heightens the risk for relapse in cocaine-dependent individuals.

Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature / LO IACONO, Luisa; Valzania, Alessandro; VISCO COMANDINI, Federica; Aricò, Eleonora; Viscomi, Maria Teresa; Castiello, Luciano; Oddi, Diego; D'Amato, Francesca R.; Bisicchia, Elisa; Ermakova, Olga; PUGLISI ALLEGRA, Stefano; Carola, Valeria. - In: ADDICTION BIOLOGY. - ISSN 1355-6215. - STAMPA. - 22:4(2016), pp. 911-922. [10.1111/adb.12373]

Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature

LO IACONO, LUISA;VALZANIA, ALESSANDRO;VISCO COMANDINI, FEDERICA;ODDI, DIEGO;PUGLISI ALLEGRA, Stefano;CAROLA, Valeria
Ultimo
2016

Abstract

Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and mediate the greater risk of relapse are poorly understood and knowledge of risk factors is to date extremely limited. In this study, we modeled childhood maltreatment by exposing juvenile mice to a threatening social experience (social stressed, S-S). We showed that S-S experience influenced the propensity to reinstate cocaineseeking after periods of withdrawal in adulthood. By exploring global gene expression in blood leukocytes we found that this behavioral phenotype was associated with greater blood coagulation. In parallel, impairments in brain microvasculature were observed in S-S mice. Furthermore, treatment with an anticoagulant agent during withdrawal abolished the susceptibility to reinstate cocaine-seeking in S-S mice. These findings provide novel insights into a possible molecular mechanism by which childhood maltreatment heightens the risk for relapse in cocaine-dependent individuals.
File allegati a questo prodotto
File Dimensione Formato  
Lo-Iacono_Social-threat_2017.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 551.61 kB
Formato Adobe PDF
551.61 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/870617
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 8
social impact