The mean age of the world population has steadily increased in the last decades, as a result of increased life expectancy and reduced birth rate. Global aging has led to a greater worldwide cost for healthcare: hormonal alterations contribute to the pathogenesis of several conditions and might cause a significant reduction in the perceived sense of well-being. Menopause is archetypal of hormonal alterations occurring during aging: in males, sex hormones do not decrease abruptly, yet testosterone levels decrease steadily and continuously during aging, ultimately resulting in late-onset hypogonadism. Treatment of this condition might mitigate most symptoms; however, testosterone replacement therapy (TRT) should be prescribed only in selected patients and it should not be considered as an antiaging treatment. In recent years, different authors have questioned health risks associated with testosterone treatment; while position statements from many scientific societies seem to be reassuring, the Food and Drug Administration has issued a warning in regard to the possible side effects of this therapy. We aim to review recent controversies and discoveries in regard to TRT.

Testosterone replacement therapy: the emperor's new clothes / Sansone, Andrea; Sansone, Massimiliano; Lenzi, Andrea; Romanelli, Francesco. - In: REJUVENATION RESEARCH (ONLINE). - ISSN 1557-8577. - STAMPA. - 20:1(2017), pp. 9-14. [10.1089/rej.2016.1818]

Testosterone replacement therapy: the emperor's new clothes

SANSONE, ANDREA;SANSONE, MASSIMILIANO;LENZI, Andrea;ROMANELLI, Francesco
2017

Abstract

The mean age of the world population has steadily increased in the last decades, as a result of increased life expectancy and reduced birth rate. Global aging has led to a greater worldwide cost for healthcare: hormonal alterations contribute to the pathogenesis of several conditions and might cause a significant reduction in the perceived sense of well-being. Menopause is archetypal of hormonal alterations occurring during aging: in males, sex hormones do not decrease abruptly, yet testosterone levels decrease steadily and continuously during aging, ultimately resulting in late-onset hypogonadism. Treatment of this condition might mitigate most symptoms; however, testosterone replacement therapy (TRT) should be prescribed only in selected patients and it should not be considered as an antiaging treatment. In recent years, different authors have questioned health risks associated with testosterone treatment; while position statements from many scientific societies seem to be reassuring, the Food and Drug Administration has issued a warning in regard to the possible side effects of this therapy. We aim to review recent controversies and discoveries in regard to TRT.
2017
aging; andropause; cardiovascular health; hormones; prostate; testosterone
01 Pubblicazione su rivista::01a Articolo in rivista
Testosterone replacement therapy: the emperor's new clothes / Sansone, Andrea; Sansone, Massimiliano; Lenzi, Andrea; Romanelli, Francesco. - In: REJUVENATION RESEARCH (ONLINE). - ISSN 1557-8577. - STAMPA. - 20:1(2017), pp. 9-14. [10.1089/rej.2016.1818]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/870452
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