Ventricular enlargement in normal aging frequently forces the radiological diagnosis of hydrocephalus, but the reliability of Evans’ index as a radiological marker of abnormal ventricular enlargement (values > 0.30) during aging is not assessed. Here we analyze ventricular size during aging and the reliability of Evans’ index as a radiological marker of abnormal ventricular enlargement. We calculated Evans’ index in the axial Computed Tomography scans of 1221 consecutive individuals (aged 45-101 years) from an emergency department. Stratified analysis of one-year cohorts showed that the mean Evans’ index value per class was invariably < 0.30. Roughly one out five Computed Tomography scans was associated with Evans’ index values > 0.30 and Evans’ index values increased with age. The risk of having an Evans’ index value > 0.30 increased by 7.8% per year of age (p < 0.001) and males were at 83.9% greater risk than females (p < 0.001). Overall, this study shows that normal aging enlarges the ventricular system, but never causes abnormal ventricular enlargement. Evans’ index values > 0.30 should reflect an underlying neurological condition in every individual.

In normal aging ventricular system never attains pathological values of Evans' index / Missori, Paolo; Rughetti, Aurelia; Peschillo, Simone; Gualdi, Gianfranco; Biasi, Claudio Di; Nofroni, Italo; Marinelli, Lucio; Fattapposta, Francesco; Curra', Antonio. - In: ONCOTARGET. - ISSN 1949-2553. - STAMPA. - (2016). [10.18632/oncotarget.7644]

In normal aging ventricular system never attains pathological values of Evans' index

MISSORI, Paolo
;
RUGHETTI, Aurelia;PESCHILLO, SIMONE;GUALDI, GIANFRANCO;NOFRONI, Italo;FATTAPPOSTA, FRANCESCO;CURRA', antonio
2016

Abstract

Ventricular enlargement in normal aging frequently forces the radiological diagnosis of hydrocephalus, but the reliability of Evans’ index as a radiological marker of abnormal ventricular enlargement (values > 0.30) during aging is not assessed. Here we analyze ventricular size during aging and the reliability of Evans’ index as a radiological marker of abnormal ventricular enlargement. We calculated Evans’ index in the axial Computed Tomography scans of 1221 consecutive individuals (aged 45-101 years) from an emergency department. Stratified analysis of one-year cohorts showed that the mean Evans’ index value per class was invariably < 0.30. Roughly one out five Computed Tomography scans was associated with Evans’ index values > 0.30 and Evans’ index values increased with age. The risk of having an Evans’ index value > 0.30 increased by 7.8% per year of age (p < 0.001) and males were at 83.9% greater risk than females (p < 0.001). Overall, this study shows that normal aging enlarges the ventricular system, but never causes abnormal ventricular enlargement. Evans’ index values > 0.30 should reflect an underlying neurological condition in every individual.
2016
Evans’ index; Gerotarget; aging; brain; enlargement; ventricular system
01 Pubblicazione su rivista::01a Articolo in rivista
In normal aging ventricular system never attains pathological values of Evans' index / Missori, Paolo; Rughetti, Aurelia; Peschillo, Simone; Gualdi, Gianfranco; Biasi, Claudio Di; Nofroni, Italo; Marinelli, Lucio; Fattapposta, Francesco; Curra', Antonio. - In: ONCOTARGET. - ISSN 1949-2553. - STAMPA. - (2016). [10.18632/oncotarget.7644]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/870314
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