More than 15% of the global cancer burden is attributable to infectious agents. Pathogens that cause persistent infections are strongly associated with cancer, inflammation being a major component of the chronic infections as revealed by basic, clinical and epidemiological studies. Persistent infection and viral oncoproteins induce specific cellular pathways modifications that promote tumorigenesis. Deregulated and continuous immune response leads to severe tissue and systemic damage, impaired tumor surveillance and consequent carcinogenesis promotion by selecting for metastatic and therapeutically resistant tumor phenotypes. In this review, the role of inflammatory microenvironment in the HPV-induced carcinogenesis is addressed, with a specific focus on the involvement of the immune molecules and microRNAs as well as their delivery through the microvesicle cargo.

Inflammatory microenvironment and human papillomavirus-induced carcinogenesis / Mangino, Giorgio; Chiantore, Maria Vincenza; Iuliano, Marco; Fiorucci, Gianna; Romeo, Giovanna. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - STAMPA. - 30:(2016), pp. 103-111. [10.1016/j.cytogfr.2016.03.007]

Inflammatory microenvironment and human papillomavirus-induced carcinogenesis

MANGINO, GIORGIO;IULIANO, MARCO;ROMEO, Giovanna
2016

Abstract

More than 15% of the global cancer burden is attributable to infectious agents. Pathogens that cause persistent infections are strongly associated with cancer, inflammation being a major component of the chronic infections as revealed by basic, clinical and epidemiological studies. Persistent infection and viral oncoproteins induce specific cellular pathways modifications that promote tumorigenesis. Deregulated and continuous immune response leads to severe tissue and systemic damage, impaired tumor surveillance and consequent carcinogenesis promotion by selecting for metastatic and therapeutically resistant tumor phenotypes. In this review, the role of inflammatory microenvironment in the HPV-induced carcinogenesis is addressed, with a specific focus on the involvement of the immune molecules and microRNAs as well as their delivery through the microvesicle cargo.
2016
cytokines/chemokines; inflammation; microRNAs; microvesicles; papillomavirus; immunology; endocrinology, diabetes and metabolism; immunology and allergy; biochemistry, genetics and molecular biology (all)
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Inflammatory microenvironment and human papillomavirus-induced carcinogenesis / Mangino, Giorgio; Chiantore, Maria Vincenza; Iuliano, Marco; Fiorucci, Gianna; Romeo, Giovanna. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - STAMPA. - 30:(2016), pp. 103-111. [10.1016/j.cytogfr.2016.03.007]
File allegati a questo prodotto
File Dimensione Formato  
Mangino_Inflammatory-microenvironment_2016 .pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.1 MB
Formato Adobe PDF
1.1 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/870249
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 29
social impact