A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxygenated stilbenes 6 and 17.

TRPA1 channels as targets for resveratrol and related stilbenoids / Nalli, Marianna; Ortar, Giorgio; Moriello, Aniello Schiano; Morera, Enrico; Di Marzo, Vincenzo; De Petrocellis, Luciano. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - ELETTRONICO. - 26:3(2016), pp. 899-902. [10.1016/j.bmcl.2015.12.065]

TRPA1 channels as targets for resveratrol and related stilbenoids

NALLI, Marianna
;
ORTAR, Giorgio;MORERA, ENRICO;
2016

Abstract

A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxygenated stilbenes 6 and 17.
2016
resveratrol; stilbenoids; TRP channels; TRPA1; TRPV1; biochemistry; clinical biochemistry; molecular biology; molecular medicine; organic chemistry; drug discovery3003 pharmaceutical science; 3003
01 Pubblicazione su rivista::01a Articolo in rivista
TRPA1 channels as targets for resveratrol and related stilbenoids / Nalli, Marianna; Ortar, Giorgio; Moriello, Aniello Schiano; Morera, Enrico; Di Marzo, Vincenzo; De Petrocellis, Luciano. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - ELETTRONICO. - 26:3(2016), pp. 899-902. [10.1016/j.bmcl.2015.12.065]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/869775
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