The COX enzymes play a central role in the biosynthetic pathway of important biological mediators called prostanoids. Differences in regulation of gene expression, stability of transcripts and proteins determine the different biological functions of COX-1 and COX-2. While the COX-1 gene has been considered to be a ‘housekeeping’ gene expressed in many tissues and cells, COX-2 gene is upregulated during inflammation, hypoxia and in many cancers.
COX inhibitors: a patent review (2011 - 2014) / Consalvi, Sara; Biava, Mariangela; Poce, Giovanna. - In: EXPERT OPINION ON THERAPEUTIC PATENTS. - ISSN 1354-3776. - STAMPA. - 25:(2015), pp. 1357-1371. [10.1517/13543776.2015.1090973]
COX inhibitors: a patent review (2011 - 2014)
CONSALVI, SARA;BIAVA, Mariangela
;POCE, Giovanna
2015
Abstract
The COX enzymes play a central role in the biosynthetic pathway of important biological mediators called prostanoids. Differences in regulation of gene expression, stability of transcripts and proteins determine the different biological functions of COX-1 and COX-2. While the COX-1 gene has been considered to be a ‘housekeeping’ gene expressed in many tissues and cells, COX-2 gene is upregulated during inflammation, hypoxia and in many cancers.| File | Dimensione | Formato | |
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