BACKGROUND: The aim of this study was to evaluate the long-term effects of laparoscopic sleeve gastrectomy (LSG) on type 2 diabetes mellitus (T2DM) and other related co-morbidities in severely obese patients. METHODS: From May 2003 to July 2008, 33 morbidly obese diabetic patients (20 with body mass index [BMI]>50 kg/m(2)) underwent LSG. A total of 23 females and 10 males participated, with a mean age of 49.3±8 years, mean preoperative BMI of 52.1±8.5 kg/m(2), mean fasting plasma glucose (FPG) of 143.2±47.9 mg/dL, mean glycosylated hemoglobin (HbA(1c)) of 7.3%±1.4%, and a mean T2DM duration of 7 years. All patients had a 36-month follow-up, and 13 had a 60-month follow-up. RESULTS: Twenty-nine patients (87.8%) discontinued antidiabetic medications 3 months after LSG, (mean BMI of 42.8±7.8 kg/m(2); FPG of 104.5±22.1 mg/dL; HbA(1c) of 5.3%±.4%). At 36 months, 22 of 26 LSG patients (84.6%) had normal FPG and HbA(1c) values without antidiabetic therapy. At the 60-month follow-up, 10 of 13 patients (76.9%) had normal FPG and HbA(1c) values without antidiabetic therapy. The Framingham risk score decreased significantly from 9.7% preoperatively to 4.7% postoperatively. No new diabetic retinopathy occurred during the whole period of observation. CONCLUSIONS: This study confirms the efficacy of LSG in the treatment of T2DM and indicates that, at both 36- and 60-month follow-ups, LSG can provide a significant percentage of treated patients with a prolonged remission of T2DM, with diminished cardiac risk factors and no development of diabetic retinopathy. These results compare favorably with those reported after standard medical therapy.

Long-term remission of type 2 diabetes in morbidly obese patients after sleeve gastrectomy / Abbatini, Francesca; Capoccia, Danila; Casella, Giovanni; Soricelli, Emanuele; Leonetti, Frida; Basso, Nicola. - In: SURGERY FOR OBESITY AND RELATED DISEASES. - ISSN 1550-7289. - STAMPA. - 9:4(2013), pp. 498-502. [10.1016/j.soard.2012.09.003]

Long-term remission of type 2 diabetes in morbidly obese patients after sleeve gastrectomy

ABBATINI, FRANCESCA;CAPOCCIA, DANILA;CASELLA, GIOVANNI;SORICELLI, EMANUELE;LEONETTI, Frida;BASSO, Nicola
2013

Abstract

BACKGROUND: The aim of this study was to evaluate the long-term effects of laparoscopic sleeve gastrectomy (LSG) on type 2 diabetes mellitus (T2DM) and other related co-morbidities in severely obese patients. METHODS: From May 2003 to July 2008, 33 morbidly obese diabetic patients (20 with body mass index [BMI]>50 kg/m(2)) underwent LSG. A total of 23 females and 10 males participated, with a mean age of 49.3±8 years, mean preoperative BMI of 52.1±8.5 kg/m(2), mean fasting plasma glucose (FPG) of 143.2±47.9 mg/dL, mean glycosylated hemoglobin (HbA(1c)) of 7.3%±1.4%, and a mean T2DM duration of 7 years. All patients had a 36-month follow-up, and 13 had a 60-month follow-up. RESULTS: Twenty-nine patients (87.8%) discontinued antidiabetic medications 3 months after LSG, (mean BMI of 42.8±7.8 kg/m(2); FPG of 104.5±22.1 mg/dL; HbA(1c) of 5.3%±.4%). At 36 months, 22 of 26 LSG patients (84.6%) had normal FPG and HbA(1c) values without antidiabetic therapy. At the 60-month follow-up, 10 of 13 patients (76.9%) had normal FPG and HbA(1c) values without antidiabetic therapy. The Framingham risk score decreased significantly from 9.7% preoperatively to 4.7% postoperatively. No new diabetic retinopathy occurred during the whole period of observation. CONCLUSIONS: This study confirms the efficacy of LSG in the treatment of T2DM and indicates that, at both 36- and 60-month follow-ups, LSG can provide a significant percentage of treated patients with a prolonged remission of T2DM, with diminished cardiac risk factors and no development of diabetic retinopathy. These results compare favorably with those reported after standard medical therapy.
2013
Bariatric; Metabolic surgery; Obesity; Sleeve gastrectomy; Type 2 diabetes; Cholesterol, HDL; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gastrectomy; Hemoglobin A, Glycosylated; Humans; Hypoglycemic Agents; Laparoscopy; Male; Middle Aged; Obesity, Morbid; Treatment Outcome; Weight Loss; Surgery
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Long-term remission of type 2 diabetes in morbidly obese patients after sleeve gastrectomy / Abbatini, Francesca; Capoccia, Danila; Casella, Giovanni; Soricelli, Emanuele; Leonetti, Frida; Basso, Nicola. - In: SURGERY FOR OBESITY AND RELATED DISEASES. - ISSN 1550-7289. - STAMPA. - 9:4(2013), pp. 498-502. [10.1016/j.soard.2012.09.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/869202
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