In patients affected by insulin resistance (IR), metformin (MET) therapy has been shown to exert its positive effects by improving glucose tolerance and preventing the evolution to diabetes. Recently, it was shown that the addition of metformin to physical training did not improve sensitivity to insulin or peak oxygen consumption (peak VO2). The purpose of this study was to establish the effect of metformin and exercise, separately or in combination, on systolic left ventricular (LV) function in individuals with IR.
Effects of Metformin and Exercise Training, Alone or in Combination, on Cardiac Function in Individuals with Insulin Resistance / Cadeddu, Christian; Nocco, Silvio; Cugusi, Lucia; Deidda, Martino; Fabio, Orru; Bandino, Stefano; Cossu, Efisio; Incani, Michela; Baroni, Marco Giorgio; Mercuro, Giuseppe. - In: CARDIOLOGY AND THERAPY. - ISSN 2193-8261. - Feb 1. [Epub ahead of print]:(2016), pp. 1-11. [10.1007/s40119-016-0057-3]
Effects of Metformin and Exercise Training, Alone or in Combination, on Cardiac Function in Individuals with Insulin Resistance
INCANI, MICHELA;BARONI, Marco Giorgio;
2016
Abstract
In patients affected by insulin resistance (IR), metformin (MET) therapy has been shown to exert its positive effects by improving glucose tolerance and preventing the evolution to diabetes. Recently, it was shown that the addition of metformin to physical training did not improve sensitivity to insulin or peak oxygen consumption (peak VO2). The purpose of this study was to establish the effect of metformin and exercise, separately or in combination, on systolic left ventricular (LV) function in individuals with IR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
