The palladium-catalyzed reaction of propargylic carbonates with Meldrum’s acid derivatives proceeds smoothly in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give substitution products. The substitution products can be useful intermediates for the stereoselective synthesis of functionalized (Z)-γ-alkylidene-γ-butyrolactones
Palladium-catalyzed nucleophilic substitution of propargylic carbonates and meldrum's acid derivatives / Ambrogio, Ilaria; Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Iazzetti, Antonia. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2015:14(2015), pp. 3147-3151. [10.1002/ejoc.201500337]
Palladium-catalyzed nucleophilic substitution of propargylic carbonates and meldrum's acid derivatives
CACCHI, Sandro;FABRIZI, Giancarlo;GOGGIAMANI, ANTONELLA
;IAZZETTI, Antonia
2015
Abstract
The palladium-catalyzed reaction of propargylic carbonates with Meldrum’s acid derivatives proceeds smoothly in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give substitution products. The substitution products can be useful intermediates for the stereoselective synthesis of functionalized (Z)-γ-alkylidene-γ-butyrolactones| File | Dimensione | Formato | |
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