Evidences have shown the presence ofmultipotent stemcells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.

Adult vascular wall-resident multipotent vascular stem cells, matrix metalloproteinases and arterial aneurysms / Amato, B; Compagna, R; Amato, M; Grande, Raffaele; Butrico, L; Rossi, A; Naso, A; Ruggiero, M; de Franciscis, S; Serra, R.. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - STAMPA. - 2015:(2015). [10.1155/2015/434962]

Adult vascular wall-resident multipotent vascular stem cells, matrix metalloproteinases and arterial aneurysms

GRANDE, RAFFAELE;Butrico, L;
2015

Abstract

Evidences have shown the presence ofmultipotent stemcells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.
2015
varicose ulcer; venous ulceration
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Adult vascular wall-resident multipotent vascular stem cells, matrix metalloproteinases and arterial aneurysms / Amato, B; Compagna, R; Amato, M; Grande, Raffaele; Butrico, L; Rossi, A; Naso, A; Ruggiero, M; de Franciscis, S; Serra, R.. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - STAMPA. - 2015:(2015). [10.1155/2015/434962]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/867426
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