Critical limb ischaemia (CLI) is the most advanced form of peripheral artery disease (PAD) and it is often associated with foot gangrene, which may lead to major amputation of lower limbs, and also with a higher risk of death due to fatal cardiovascular events. Matrix metalloproteinases (MMPs) seem to be involved in atherosclerosis, PAD and CLI. Aim of this study was to evaluate variations in MMP serum levels in patients affected by CLI, before and after lower limb surgical revascularisation through prosthetic or venous bypass. A total of 29 patients (7 females and 22 males, mean age 73·4 years, range 65–83 years) suffering from CLI and submitted to lower extremity bypass (LEB) in our Institution were recruited. Seven patients (group I) underwent LEB using synthetic polytetrafluoroethylene (PTFE) graft material and 22 patients (group II) underwent LEB using autogenous veins. Moreover, 30 healthy age-sex-matched subjects were also enrolled as controls (group III). We documented significantly higher serum MMPs levels (P < 0·01) in patients with CLI (groups I and II) with respect to control group (group III). Finally, five patients with CLI (17·2%) showed poor outcomes (major amputations or death), and enzyme-linked immunosorbent assay (ELISA) test showed very high levels of MMP-1 and MMP-8. MMP serum levels seem to be able to predict the clinical outcomes of patients with CLI.

Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia / De Caridi, G; Massara, M; Spinelli, F; David, A; Gangemi, S; Fugetto, F; Grande, R; Butrico, L; Stefanelli, R; Colosimo, M; de Franciscis, S; Serra, R. - In: INTERNATIONAL WOUND JOURNAL. - ISSN 1742-4801. - STAMPA. - 13:4(2016), pp. 493-499. [10.1111/iwj.12464]

Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia

Grande, R;Butrico, L;Stefanelli, R;
2016

Abstract

Critical limb ischaemia (CLI) is the most advanced form of peripheral artery disease (PAD) and it is often associated with foot gangrene, which may lead to major amputation of lower limbs, and also with a higher risk of death due to fatal cardiovascular events. Matrix metalloproteinases (MMPs) seem to be involved in atherosclerosis, PAD and CLI. Aim of this study was to evaluate variations in MMP serum levels in patients affected by CLI, before and after lower limb surgical revascularisation through prosthetic or venous bypass. A total of 29 patients (7 females and 22 males, mean age 73·4 years, range 65–83 years) suffering from CLI and submitted to lower extremity bypass (LEB) in our Institution were recruited. Seven patients (group I) underwent LEB using synthetic polytetrafluoroethylene (PTFE) graft material and 22 patients (group II) underwent LEB using autogenous veins. Moreover, 30 healthy age-sex-matched subjects were also enrolled as controls (group III). We documented significantly higher serum MMPs levels (P < 0·01) in patients with CLI (groups I and II) with respect to control group (group III). Finally, five patients with CLI (17·2%) showed poor outcomes (major amputations or death), and enzyme-linked immunosorbent assay (ELISA) test showed very high levels of MMP-1 and MMP-8. MMP serum levels seem to be able to predict the clinical outcomes of patients with CLI.
2016
amputation; foot gangrene; matrix metalloproteinases; peripheral artery disease; revascularisation
01 Pubblicazione su rivista::01a Articolo in rivista
Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia / De Caridi, G; Massara, M; Spinelli, F; David, A; Gangemi, S; Fugetto, F; Grande, R; Butrico, L; Stefanelli, R; Colosimo, M; de Franciscis, S; Serra, R. - In: INTERNATIONAL WOUND JOURNAL. - ISSN 1742-4801. - STAMPA. - 13:4(2016), pp. 493-499. [10.1111/iwj.12464]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/867423
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