Obesity is associated with many pathological conditions. Tumor Necrosis Factor-α (TNF-α) is one of the key mediators of inflammation involved in the obesity-related insulin resistance development. We aim to review the human evidence useful to clarify the relationship between inflammation and body weight, with particular reference to TNF-α. Genetic polymorphisms and epigenetic factors, such as diet, could affect TNF-α activity. TNF-α is associated with obesity, but also with anorexia and cachexia. Despite the role of TNF-α in obesity-related diseases, anti-TNF-α antibody therapy is associated with an increase in adiposity. In conclusion the reviewed results suggest that inflammation is more likely a consequence rather than a cause of obesity
The relationship between body weight and inflammation: Lesson from anti-TNF-α antibody therapy / Peluso, Ilaria; Palmery, Maura. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - ELETTRONICO. - 77:1(2015), pp. 47-53-53. [10.1016/j.humimm.2015.10.008]
The relationship between body weight and inflammation: Lesson from anti-TNF-α antibody therapy
PALMERY, Maura
2015
Abstract
Obesity is associated with many pathological conditions. Tumor Necrosis Factor-α (TNF-α) is one of the key mediators of inflammation involved in the obesity-related insulin resistance development. We aim to review the human evidence useful to clarify the relationship between inflammation and body weight, with particular reference to TNF-α. Genetic polymorphisms and epigenetic factors, such as diet, could affect TNF-α activity. TNF-α is associated with obesity, but also with anorexia and cachexia. Despite the role of TNF-α in obesity-related diseases, anti-TNF-α antibody therapy is associated with an increase in adiposity. In conclusion the reviewed results suggest that inflammation is more likely a consequence rather than a cause of obesityI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.