This overview follows the evolution of the studies carried out, mainly during last years, on polysaccharide hydrogels, with particular attention on the researches carried out in our department, often in collaboration with other groups in our country and abroad. The review points out the importance of this type of networks for the optimization of drug delivery and targeting in the various forms of macro, micro and nano systems. It is also shown that these materials are suitable for the culture of different types of cells. Release mechanisms are reported and explained by different physico-chemical approaches and by means of molecular dynamics simulations and the anomalous swelling behavior of a scleroglucan/borax hydrogel is thoroughly discussed. The role of polymer combinations forming interpenetrated structures is explained in terms of specific properties which significantly differ from those of the constituent polymers, thus allowing appropriate tailoring of the delivery rates. Finally the wide possibilities of applications of nanogel structures which allow combination therapies for cancer treatment and can be suitable for intracellular targeting are reported. The studies on polysaccharide hydrogels are still in progress and it is underlined that future researches, more focused on the passage from lab to market, should be further stimulated.

From macro to nano polysaccharide hydrogels: an opportunity for the delivery of drugs / Alhaique, Franco; Casadei, Maria Antonietta; Cencetti, Claudia; Coviello, Tommasina; DI MEO, Chiara; Matricardi, Pietro; Montanari, Elita; Pacelli, Settimio; Paolicelli, Patrizia. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - ELETTRONICO. - 32:(2016), pp. 88-99. [10.1016/j.jddst.2015.09.018]

From macro to nano polysaccharide hydrogels: an opportunity for the delivery of drugs

ALHAIQUE, Franco
;
CASADEI, Maria Antonietta;CENCETTI, Claudia;COVIELLO, Tommasina;DI MEO, Chiara;MATRICARDI, PIETRO;MONTANARI, ELITA;PACELLI, SETTIMIO;PAOLICELLI, PATRIZIA
2016

Abstract

This overview follows the evolution of the studies carried out, mainly during last years, on polysaccharide hydrogels, with particular attention on the researches carried out in our department, often in collaboration with other groups in our country and abroad. The review points out the importance of this type of networks for the optimization of drug delivery and targeting in the various forms of macro, micro and nano systems. It is also shown that these materials are suitable for the culture of different types of cells. Release mechanisms are reported and explained by different physico-chemical approaches and by means of molecular dynamics simulations and the anomalous swelling behavior of a scleroglucan/borax hydrogel is thoroughly discussed. The role of polymer combinations forming interpenetrated structures is explained in terms of specific properties which significantly differ from those of the constituent polymers, thus allowing appropriate tailoring of the delivery rates. Finally the wide possibilities of applications of nanogel structures which allow combination therapies for cancer treatment and can be suitable for intracellular targeting are reported. The studies on polysaccharide hydrogels are still in progress and it is underlined that future researches, more focused on the passage from lab to market, should be further stimulated.
2016
drug delivery; hydrogels; interpenetrated polymer networks; nanohydrogels; polysaccharides; targeting; 3003
01 Pubblicazione su rivista::01a Articolo in rivista
From macro to nano polysaccharide hydrogels: an opportunity for the delivery of drugs / Alhaique, Franco; Casadei, Maria Antonietta; Cencetti, Claudia; Coviello, Tommasina; DI MEO, Chiara; Matricardi, Pietro; Montanari, Elita; Pacelli, Settimio; Paolicelli, Patrizia. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - ELETTRONICO. - 32:(2016), pp. 88-99. [10.1016/j.jddst.2015.09.018]
File allegati a questo prodotto
File Dimensione Formato  
Alhaique_From-macro_2016.pdf

solo gestori archivio

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.9 MB
Formato Adobe PDF
2.9 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/867389
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 22
social impact