To control liposomes fate and transport upon contact with biofluids, it is essential to consider several parameters affecting the synthetic and biological identity of liposomes, as well as liposome−protein corona (PC) aspects. As a powerful tool in this data mining adventure, quantitative structure−activity relationship (QSAR) ap- proach is used to correlate physicochemical properties of liposomes and their PC fingerprints to multiple quantified biological responses. In the present study, the relationship between cellular interactions of a set of structurally diverse liposomal formulations and their physicochemical and PC properties has been investigated via linear and nonlinear QSAR models. Significant parameters affecting cellular uptake and cell viability of liposomes in two important cancer cell lines (PC3 and HeLa) have been identified. The developed QSARs have the capacity to be implemented in advanced targeted delivery of liposomal drugs.
Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties / Bigdeli, Arafeh; Palchetti, Sara; Pozzi, Daniela; Hormozi Nezhad, Mohammad Reza; Baldelli Bombelli, Francesca; Caracciolo, Giulio; Mahmoudi, Morteza. - In: ACS NANO. - ISSN 1936-0851. - ELETTRONICO. - 10:3(2016), pp. 3723-3737. [10.1021/acsnano.6b00261]
Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties
PALCHETTI, SARA;POZZI, DANIELA;CARACCIOLO, Giulio;
2016
Abstract
To control liposomes fate and transport upon contact with biofluids, it is essential to consider several parameters affecting the synthetic and biological identity of liposomes, as well as liposome−protein corona (PC) aspects. As a powerful tool in this data mining adventure, quantitative structure−activity relationship (QSAR) ap- proach is used to correlate physicochemical properties of liposomes and their PC fingerprints to multiple quantified biological responses. In the present study, the relationship between cellular interactions of a set of structurally diverse liposomal formulations and their physicochemical and PC properties has been investigated via linear and nonlinear QSAR models. Significant parameters affecting cellular uptake and cell viability of liposomes in two important cancer cell lines (PC3 and HeLa) have been identified. The developed QSARs have the capacity to be implemented in advanced targeted delivery of liposomal drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
