Genetic factors exert an important role in determining Systemic Lupus Erythematosus (SLE) susceptibility, interplaying with environmental factors. Several genetic studies in various SLE populations have identified numerous susceptibility loci. From a clinical point of view, SLE is characterized by a great heterogeneity in terms of clinical and laboratory manifestations. As widely demonstrated, specific laboratory features are associated with clinical disease subset, with different severity degree. Similarly, in the last years, an association between specific phenotypes and genetic variants has been identified, allowing the possibility to elucidate different mechanisms and pathways accountable for disease manifestations. However, except for Lupus Nephritis (LN), no studies have been designed to identify the genetic variants associated with the development of different phenotypes. In this review, we will report data currently known about this specific association.

Genetic factors in systemic lupus erythematosus: Contribution to disease phenotype / Ceccarelli, Fulvia; Perricone, Carlo; Borgiani, Paola; Ciccacci, Cinzia; Rufini, Sara; Cipriano, Enrica; Alessandri, Cristiano; Spinelli, FRANCESCA ROMANA; SILI SCAVALLI, Antonio; Novelli, Giuseppe; Valesini, Guido; Conti, Fabrizio. - In: JOURNAL OF IMMUNOLOGY RESEARCH. - ISSN 2314-8861. - STAMPA. - 2015:(2015), pp. 1-11. [10.1155/2015/745647]

Genetic factors in systemic lupus erythematosus: Contribution to disease phenotype

CECCARELLI, FULVIA;PERRICONE, CARLO;CIPRIANO, ENRICA;ALESSANDRI, cristiano;SPINELLI, FRANCESCA ROMANA;SILI SCAVALLI, Antonio;VALESINI, Guido;CONTI, FABRIZIO
2015

Abstract

Genetic factors exert an important role in determining Systemic Lupus Erythematosus (SLE) susceptibility, interplaying with environmental factors. Several genetic studies in various SLE populations have identified numerous susceptibility loci. From a clinical point of view, SLE is characterized by a great heterogeneity in terms of clinical and laboratory manifestations. As widely demonstrated, specific laboratory features are associated with clinical disease subset, with different severity degree. Similarly, in the last years, an association between specific phenotypes and genetic variants has been identified, allowing the possibility to elucidate different mechanisms and pathways accountable for disease manifestations. However, except for Lupus Nephritis (LN), no studies have been designed to identify the genetic variants associated with the development of different phenotypes. In this review, we will report data currently known about this specific association.
File allegati a questo prodotto
File Dimensione Formato  
Ceccarelli_Genetic-factors_2015.pdf

accesso aperto

Note: file pdf
Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 688.3 kB
Formato Adobe PDF
688.3 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/865515
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 69
  • ???jsp.display-item.citation.isi??? 51
social impact