Abstract In glomerulonephritis we find various anatomical and pathological aspects of the kidneys, despite the clinical manifestations are almost identical (haematuria, proteinuria, nephrotic or nephritic syndrome). The anatomical damage and the clinical manifestations is produced by a known or unknown antigenic insult, in relation to the predisposing genetic factors and to the defences predisposed by the immunological system. From the '80, some publications showed an immunological pathogenesis of the glomerulonephritis, with the participation of haematological elements such as lymphoid cells. Therefore, the pathogenesis of the primitive glomerulonephritis are in great part unknown, although we know that the increased permeability of the glomerular capillary is correlated to the production of proinflammatory lymphokines from T cells, which are overexpressed (RANTES). Not to succeed to adequately eliminate these cells can be, thus, a cause of relapse with the final result of renal infiltration and amplification of the immune response.

Glomerulonephritis / Russo, Gaspare Elios; Morgia, Augusto; Cavallini, Marco. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 158:6(2007), pp. 495-496.

Glomerulonephritis

RUSSO, Gaspare Elios;MORGIA, AUGUSTO;CAVALLINI, MARCO
2007

Abstract

Abstract In glomerulonephritis we find various anatomical and pathological aspects of the kidneys, despite the clinical manifestations are almost identical (haematuria, proteinuria, nephrotic or nephritic syndrome). The anatomical damage and the clinical manifestations is produced by a known or unknown antigenic insult, in relation to the predisposing genetic factors and to the defences predisposed by the immunological system. From the '80, some publications showed an immunological pathogenesis of the glomerulonephritis, with the participation of haematological elements such as lymphoid cells. Therefore, the pathogenesis of the primitive glomerulonephritis are in great part unknown, although we know that the increased permeability of the glomerular capillary is correlated to the production of proinflammatory lymphokines from T cells, which are overexpressed (RANTES). Not to succeed to adequately eliminate these cells can be, thus, a cause of relapse with the final result of renal infiltration and amplification of the immune response.
2007
01 Pubblicazione su rivista::01a Articolo in rivista
Glomerulonephritis / Russo, Gaspare Elios; Morgia, Augusto; Cavallini, Marco. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 158:6(2007), pp. 495-496.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/86504
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