The microaerophilic protist Giardia intestinalis is the causative agent of giardiasis, one of the most common intestinal infectious diseases worldwide. The pathogen lacks not only respiratory terminal oxidases (being amitochondriate), but also several conventional antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase. In spite of this, since living attached to the mucosa of the proximal small intestine, the parasite should rely on an efficient antioxidant system to survive the oxidative and nitrosative stress conditions found in this tract of the human gut. Here, we review current knowledge on the antioxidant defence systems in G. intestinalis, focusing on the progress made over the last decade in the field. The relevance of this research and future perspectives are discussed.

Antioxidant defence systems in the protozoan pathogen giardia intestinalis / Mastronicola, Daniela; Falabella, Micol; Forte, Elena; Testa, Fabrizio; Sarti, Paolo; Giuffre', Alessandro. - In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. - ISSN 0166-6851. - STAMPA. - (2015). [10.1016/j.molbiopara.2015.12.002]

Antioxidant defence systems in the protozoan pathogen giardia intestinalis

MASTRONICOLA, Daniela;FALABELLA, MICOL;FORTE, Elena;TESTA, FABRIZIO;SARTI, Paolo;GIUFFRE', ALESSANDRO
2015

Abstract

The microaerophilic protist Giardia intestinalis is the causative agent of giardiasis, one of the most common intestinal infectious diseases worldwide. The pathogen lacks not only respiratory terminal oxidases (being amitochondriate), but also several conventional antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase. In spite of this, since living attached to the mucosa of the proximal small intestine, the parasite should rely on an efficient antioxidant system to survive the oxidative and nitrosative stress conditions found in this tract of the human gut. Here, we review current knowledge on the antioxidant defence systems in G. intestinalis, focusing on the progress made over the last decade in the field. The relevance of this research and future perspectives are discussed.
anaerobic protozoa; drug targets; enzymatic detoxification; intestinal infectious diseases; oxidative and nitrosative stress; recombinant enzymes; molecular biology; parasitology
01 Pubblicazione su rivista::01a Articolo in rivista
Antioxidant defence systems in the protozoan pathogen giardia intestinalis / Mastronicola, Daniela; Falabella, Micol; Forte, Elena; Testa, Fabrizio; Sarti, Paolo; Giuffre', Alessandro. - In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. - ISSN 0166-6851. - STAMPA. - (2015). [10.1016/j.molbiopara.2015.12.002]
File allegati a questo prodotto
File Dimensione Formato  
Mastronicola_Antioxidant_2015

solo gestori archivio

Note: Articolo principale
Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.23 MB
Formato Adobe PDF
2.23 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/862792
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 17
social impact