Background: Several researches have shown that acidification of tumor microenvironment is the basis for tumor invasiveness, ability to metastasize S382 Abstracts and cytotoxic agents resistance; therefore proton pump inhibitors (PPI) could significantly increase the chemosensitivity. In our retrospective work we have investigated the role of capecitabine (mCAP) at metronomic dosage of 1500 mg/die as salvage chemotherapy in patients with metastatic colorectal cancer, showing a moderately activity and well tolerability. In this prospective study we evaluated safety and activity of mCAP in the advanced gastro-intestinal patients and the putative chemosensitizing activity of a specific PPI (Rabeprazole) in association to this therapy
Association between proton-pump inhibitors (PPI) and metronomic capecitabine (MCAP) as salvage treatment for patients with advanced gastro-intestinal tumoursa. A randomized phase II study / Milano, Annalisa; D'Antonio, Chiara; Roberto, Michela; Falcone, Rosa; DI PIETRO, FRANCESCA ROMANA; Durante, Valeria; Romiti, Adriana; Marchetti, P.. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - ELETTRONICO. - 51:Suppl. 3(2015), pp. 381-382. (Intervento presentato al convegno European Cancer Congress 2015 (ECC 2015) tenutosi a Wien Austria nel 25 - 29 September) [10.1016/S0959-8049(16)31067-X].
Association between proton-pump inhibitors (PPI) and metronomic capecitabine (MCAP) as salvage treatment for patients with advanced gastro-intestinal tumoursa. A randomized phase II study
MILANO, ANNALISA;D'ANTONIO, CHIARA;ROBERTO, MICHELA;FALCONE, ROSA;DI PIETRO, FRANCESCA ROMANA;DURANTE, VALERIA;ROMITI, ADRIANA;Marchetti, P.
2015
Abstract
Background: Several researches have shown that acidification of tumor microenvironment is the basis for tumor invasiveness, ability to metastasize S382 Abstracts and cytotoxic agents resistance; therefore proton pump inhibitors (PPI) could significantly increase the chemosensitivity. In our retrospective work we have investigated the role of capecitabine (mCAP) at metronomic dosage of 1500 mg/die as salvage chemotherapy in patients with metastatic colorectal cancer, showing a moderately activity and well tolerability. In this prospective study we evaluated safety and activity of mCAP in the advanced gastro-intestinal patients and the putative chemosensitizing activity of a specific PPI (Rabeprazole) in association to this therapy| File | Dimensione | Formato | |
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