A three-allele polymorphic system is detectable by direct electrophoretic analysis of the amplified 5' untranslated und 5' flanking regions of the HLA-linked HSP70-1 gene. Single nucleotide differences at two sites, i. e., - 110 and + 120, are responsible for changes in the bending pattern and, consequently, in the electrophoretic mobility of the three alleles. The presence of the sequence AAACCCC around position - 110 is strongly associated with DR3.
STRONG GENETIC ASSOCIATION BETWEEN HLA-DR3 AND A POLYMORPHIC VARIATION IN THE REGULATORY REGION OF THE HSP70-1 GENE / I., Cascino; Sorrentino, Rosa; R., Tosi. - In: IMMUNOGENETICS. - ISSN 0093-7711. - 37:3(1993), pp. 177-182.
STRONG GENETIC ASSOCIATION BETWEEN HLA-DR3 AND A POLYMORPHIC VARIATION IN THE REGULATORY REGION OF THE HSP70-1 GENE
SORRENTINO, Rosa;
1993
Abstract
A three-allele polymorphic system is detectable by direct electrophoretic analysis of the amplified 5' untranslated und 5' flanking regions of the HLA-linked HSP70-1 gene. Single nucleotide differences at two sites, i. e., - 110 and + 120, are responsible for changes in the bending pattern and, consequently, in the electrophoretic mobility of the three alleles. The presence of the sequence AAACCCC around position - 110 is strongly associated with DR3.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
