The biliary tree stem cell compartment is activated in PSC, its activation contributes to biliary fibrosis, and is sustained by the Hedgehog pathway. Our findings suggest a key role for peribiliary glands in the progression of bile duct lesions in PSC and could explain the associated high risk of cholangiocarcinoma.
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis / Carpino, G., Cardinale, V., Renzi, A., Hov, J.R., Berloco, P.B., Rossi, M., Karlsen, T.H., Alvaro, D., Gaudio, E.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 63:5(2015), pp. 1220-1228. [10.1016/j.jhep.2015.06.018]
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
CARDINALE, VINCENZO;RENZI, ANASTASIA;BERLOCO, Pasquale Bartolomeo;ROSSI, MASSIMO;ALVARO, Domenico;GAUDIO, EUGENIO
2015
Abstract
The biliary tree stem cell compartment is activated in PSC, its activation contributes to biliary fibrosis, and is sustained by the Hedgehog pathway. Our findings suggest a key role for peribiliary glands in the progression of bile duct lesions in PSC and could explain the associated high risk of cholangiocarcinoma.File allegati a questo prodotto
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