The biliary tree stem cell compartment is activated in PSC, its activation contributes to biliary fibrosis, and is sustained by the Hedgehog pathway. Our findings suggest a key role for peribiliary glands in the progression of bile duct lesions in PSC and could explain the associated high risk of cholangiocarcinoma.
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis / Carpino, Guido; Cardinale, Vincenzo; Renzi, Anastasia; Hov, Johannes R.; Berloco, Pasquale Bartolomeo; Rossi, Massimo; Karlsen, Tom H.; Alvaro, Domenico; Gaudio, Eugenio. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 63:5(2015), pp. 1220-1228. [10.1016/j.jhep.2015.06.018]