Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs.

Long Noncoding RNA Regulation of Pluripotency / Rosa, Alessandro; Ballarino, Monica. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - ELETTRONICO. - 2016:(2016), pp. 1-9. [10.1155/2016/1797692]

Long Noncoding RNA Regulation of Pluripotency

ROSA, ALESSANDRO;BALLARINO, MONICA
2016

Abstract

Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs.
2016
Cell Biology; Molecular Biology; embryonic stem-cells; self-renewal; gene-expression
01 Pubblicazione su rivista::01a Articolo in rivista
Long Noncoding RNA Regulation of Pluripotency / Rosa, Alessandro; Ballarino, Monica. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - ELETTRONICO. - 2016:(2016), pp. 1-9. [10.1155/2016/1797692]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/845821
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