To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region relatively spared. We wondered whether changes in the expression of individual mGlu receptor subtypes selectively occur in the vulnerable CA1 region during the development of ischemic damage, and whether post-ischemic treatment with drugs targeting the selected receptor(s) affords neuroprotection.
Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage / Motolese, Marta; Mastroiacovo, Federica; Cannella, Milena; Bucci, Domenico; Gaglione, Anderson; Riozzi, Barbara; Lütjens, Robert; Poli, Sonia M; Celanire, Sylvain; Bruno, Valeria Maria Gloria; Battaglia, Giuseppe; Nicoletti, Ferdinando. - In: MOLECULAR BRAIN. - ISSN 1756-6606. - 8:1(2015), p. 66. [10.1186/s13041-015-0158-2]
Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage
MOTOLESE, MARTA;BRUNO, Valeria Maria Gloria;BATTAGLIA, Giuseppe;NICOLETTI, Ferdinando
2015
Abstract
To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region relatively spared. We wondered whether changes in the expression of individual mGlu receptor subtypes selectively occur in the vulnerable CA1 region during the development of ischemic damage, and whether post-ischemic treatment with drugs targeting the selected receptor(s) affords neuroprotection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.