In this study, flunarizine, a selective calcium-channel blocker, was employed in the prophylactic treatment of headache and was compared with methysergide in terms of efficacy. The trial was conducted with 104 patients (53 treated with flunarizine and 51 treated with methysergide) and lasted six months--one month of pretreatment and five months of therapy. Patients in both groups experienced a highly significant reduction in the number and duration of migraine attacks. Unlike those in the methysergide group, patients treated with flunarizine achieved a significant reduction in the intensity of attacks with very negligible side effects.
Prophylaxis of migraine attacks with a calcium-channel blocker: flunarizine versus methysergide / Steardo, Luca; Marano, E; Barone, P; Denman, Dw; Monteleone, P; Cardone, G.. - In: THE JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0091-2700. - STAMPA. - 26:(1986), pp. 524-528.
Prophylaxis of migraine attacks with a calcium-channel blocker: flunarizine versus methysergide
STEARDO, LUCA;
1986
Abstract
In this study, flunarizine, a selective calcium-channel blocker, was employed in the prophylactic treatment of headache and was compared with methysergide in terms of efficacy. The trial was conducted with 104 patients (53 treated with flunarizine and 51 treated with methysergide) and lasted six months--one month of pretreatment and five months of therapy. Patients in both groups experienced a highly significant reduction in the number and duration of migraine attacks. Unlike those in the methysergide group, patients treated with flunarizine achieved a significant reduction in the intensity of attacks with very negligible side effects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.