In this study, flunarizine, a selective calcium-channel blocker, was employed in the prophylactic treatment of headache and was compared with methysergide in terms of efficacy. The trial was conducted with 104 patients (53 treated with flunarizine and 51 treated with methysergide) and lasted six months--one month of pretreatment and five months of therapy. Patients in both groups experienced a highly significant reduction in the number and duration of migraine attacks. Unlike those in the methysergide group, patients treated with flunarizine achieved a significant reduction in the intensity of attacks with very negligible side effects.

Prophylaxis of migraine attacks with a calcium-channel blocker: flunarizine versus methysergide / Steardo, Luca; Marano, E; Barone, P; Denman, Dw; Monteleone, P; Cardone, G.. - In: THE JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0091-2700. - STAMPA. - 26:(1986), pp. 524-528.

Prophylaxis of migraine attacks with a calcium-channel blocker: flunarizine versus methysergide

STEARDO, LUCA;
1986

Abstract

In this study, flunarizine, a selective calcium-channel blocker, was employed in the prophylactic treatment of headache and was compared with methysergide in terms of efficacy. The trial was conducted with 104 patients (53 treated with flunarizine and 51 treated with methysergide) and lasted six months--one month of pretreatment and five months of therapy. Patients in both groups experienced a highly significant reduction in the number and duration of migraine attacks. Unlike those in the methysergide group, patients treated with flunarizine achieved a significant reduction in the intensity of attacks with very negligible side effects.
1986
migraine; flunarizine; methysergide
01 Pubblicazione su rivista::01a Articolo in rivista
Prophylaxis of migraine attacks with a calcium-channel blocker: flunarizine versus methysergide / Steardo, Luca; Marano, E; Barone, P; Denman, Dw; Monteleone, P; Cardone, G.. - In: THE JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0091-2700. - STAMPA. - 26:(1986), pp. 524-528.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/84443
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