Somatostatin levels in the basal ganglia are elevated in Huntington's disease. A controlled therapeutic trial of the somatostatin-depleting agent, cysteamine, was therefore conducted in five patients, including one with the rigid-akinetic form. Maximum tolerated dosage for 2 weeks produced no consistent change in extrapyramidal or dementia scores. Somatostatin concentrations were not significantly altered in plasma or CSF. Growth hormone levels, on the other hand, more than doubled, suggesting a functionally significant decrease in central somatostatin levels.

Huntington's disease: effect of cysteamine, a somatostatin-depleting agent / Shults, C; Steardo, Luca; Barone, P; Mohr, E; Juncos, J; Serrati, C; Fedio, P; Tamminga, Ca; Chase, Tn. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 36:(1986), pp. 1099-1102.

Huntington's disease: effect of cysteamine, a somatostatin-depleting agent

STEARDO, LUCA;
1986

Abstract

Somatostatin levels in the basal ganglia are elevated in Huntington's disease. A controlled therapeutic trial of the somatostatin-depleting agent, cysteamine, was therefore conducted in five patients, including one with the rigid-akinetic form. Maximum tolerated dosage for 2 weeks produced no consistent change in extrapyramidal or dementia scores. Somatostatin concentrations were not significantly altered in plasma or CSF. Growth hormone levels, on the other hand, more than doubled, suggesting a functionally significant decrease in central somatostatin levels.
1986
Huntington's disease; cysteamine; Growth hormone
01 Pubblicazione su rivista::01a Articolo in rivista
Huntington's disease: effect of cysteamine, a somatostatin-depleting agent / Shults, C; Steardo, Luca; Barone, P; Mohr, E; Juncos, J; Serrati, C; Fedio, P; Tamminga, Ca; Chase, Tn. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 36:(1986), pp. 1099-1102.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/84441
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