The functional role of the nucleus tractus solitarius (NTS) in the regulation of arginine-vasopressin (AVP) release mediated by baroreceptor activation was investigated by examining the effects induced by the presynaptic alpha-adrenergic agonist clonidine. The present data show that microinjection of clonidine into NTS resulted in a significant attenuation of AVP secretion induced by hypovolemia in the rat. This effect produced by NTS injection of 8 and 10 nmol clonidine was prevented by NTS pretreatment with the alpha-2-adrenoceptor blocker, yohimbine (10 nmol), indicating alpha-2-adrenergic receptors were required for the biological response. These findings suggest that catecholaminergic projections from NTS to hypothalamic vasopressinergic neurons play a facilitatory role in controlling AVP secretion.

Alpha 2-adrenergic stimulation within the nucleus tractus solitarius attenuates vasopressin release induced by depletion of cardiovascular volume / Iovino, M; Vanacore, A; Steardo, Luca. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 37:(1990), pp. 821-824. [10.1016/0091-3057(90)90568-3]

Alpha 2-adrenergic stimulation within the nucleus tractus solitarius attenuates vasopressin release induced by depletion of cardiovascular volume.

STEARDO, LUCA
1990

Abstract

The functional role of the nucleus tractus solitarius (NTS) in the regulation of arginine-vasopressin (AVP) release mediated by baroreceptor activation was investigated by examining the effects induced by the presynaptic alpha-adrenergic agonist clonidine. The present data show that microinjection of clonidine into NTS resulted in a significant attenuation of AVP secretion induced by hypovolemia in the rat. This effect produced by NTS injection of 8 and 10 nmol clonidine was prevented by NTS pretreatment with the alpha-2-adrenoceptor blocker, yohimbine (10 nmol), indicating alpha-2-adrenergic receptors were required for the biological response. These findings suggest that catecholaminergic projections from NTS to hypothalamic vasopressinergic neurons play a facilitatory role in controlling AVP secretion.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/84357
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