Oscillating transcranial direct current stimulation (osc-tDCS) modulates the spontaneous brain activity in a frequency-specific manner. Most studies evaluated cortical effects of osc-tDCS through spectral analysis measures, without differentiating components associated with rhythmic and non-rhythmic activity. Since osc-tDCS mainly affects brain oscillatory activity, our aim was to investigate on the specific changes of EEG oscillations following a frontal osc-tDCS at 0.8 and at 5 Hz. 20 healthy subjects (26.8 ± 2.5 years) participated in one of two experiments (Exp.1= 0.8-Hz tDCS, n= 10; Exp.2= 5-Hz tDCS, n= 10), consisting of 3 within-subject sessions: two active conditions with different stimulation polarity (anodal osctDCS, cathodal osc-tDCS), and a control condition (sham). EEG oscillatory components (28 cortical derivations) at the stimulation frequency were measured by the Better OSCillation detection method (BOSC). Variations between before and after the osc-tDCS were compared between conditions as a function of polarity (anodal vs. cathodal vs. sham) and frequency (0.8 vs. 5 Hz) of stimulation. The main finding is a significant local increase of 0.81-Hz slow oscillations (F1,18=19.97; p=0.0004) and 5.3-Hz theta oscillations (F1,18=26.93; p= 0.0001) after 5 Hz compared to 0.8-Hz tDCS. Our study shows larger frequency-specific and cross-frequency effects of 5-Hz compared to 0.8-Hz stimulation, not revealed by conventional FFT analyses. This finding is consistent with a more effective induction of EEG synchronization during wakefulness by means of a stimulation in the theta range, and it suggests to combine measurement of EEG power and EEG oscillations in future studies involving transcranial stimulations.

Frequency-dependent effects of oscillatory-tDCS on EEG oscillations. A study with better oscillation detection method (BOSC) / D’Atri, A.; De Simoni, E.; Gorgoni, M.; Ferrara, M.; Ferlazzo, F.; Rossini, P. M.; De Gennaro, L.. - In: ARCHIVES ITALIENNES DE BIOLOGIE. - ISSN 0003-9829. - STAMPA. - 153:2-3, special issue(2015), pp. 124-134. [10.12871/000398292015237]

Frequency-dependent effects of oscillatory-tDCS on EEG oscillations. A study with better oscillation detection method (BOSC)

A. , D’Atri;E. , De Simoni;M. , Gorgoni;F. , Ferlazzo;L. , De Gennaro
2015

Abstract

Oscillating transcranial direct current stimulation (osc-tDCS) modulates the spontaneous brain activity in a frequency-specific manner. Most studies evaluated cortical effects of osc-tDCS through spectral analysis measures, without differentiating components associated with rhythmic and non-rhythmic activity. Since osc-tDCS mainly affects brain oscillatory activity, our aim was to investigate on the specific changes of EEG oscillations following a frontal osc-tDCS at 0.8 and at 5 Hz. 20 healthy subjects (26.8 ± 2.5 years) participated in one of two experiments (Exp.1= 0.8-Hz tDCS, n= 10; Exp.2= 5-Hz tDCS, n= 10), consisting of 3 within-subject sessions: two active conditions with different stimulation polarity (anodal osctDCS, cathodal osc-tDCS), and a control condition (sham). EEG oscillatory components (28 cortical derivations) at the stimulation frequency were measured by the Better OSCillation detection method (BOSC). Variations between before and after the osc-tDCS were compared between conditions as a function of polarity (anodal vs. cathodal vs. sham) and frequency (0.8 vs. 5 Hz) of stimulation. The main finding is a significant local increase of 0.81-Hz slow oscillations (F1,18=19.97; p=0.0004) and 5.3-Hz theta oscillations (F1,18=26.93; p= 0.0001) after 5 Hz compared to 0.8-Hz tDCS. Our study shows larger frequency-specific and cross-frequency effects of 5-Hz compared to 0.8-Hz stimulation, not revealed by conventional FFT analyses. This finding is consistent with a more effective induction of EEG synchronization during wakefulness by means of a stimulation in the theta range, and it suggests to combine measurement of EEG power and EEG oscillations in future studies involving transcranial stimulations.
2015
sleep; EEG analysis; BOSC; FFT
01 Pubblicazione su rivista::01a Articolo in rivista
Frequency-dependent effects of oscillatory-tDCS on EEG oscillations. A study with better oscillation detection method (BOSC) / D’Atri, A.; De Simoni, E.; Gorgoni, M.; Ferrara, M.; Ferlazzo, F.; Rossini, P. M.; De Gennaro, L.. - In: ARCHIVES ITALIENNES DE BIOLOGIE. - ISSN 0003-9829. - STAMPA. - 153:2-3, special issue(2015), pp. 124-134. [10.12871/000398292015237]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/843445
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