As the knowledge on cancer genetic alterations progresses, it fosters the need for more personalized therapeutic intervention in modern cancer management. Recently, mutations in KRAS, BRAF, and PIK3CA genes have emerged as important mechanisms of resistance to EGFR-targeted therapy in metastatic colorectal cancer (mCRC). Here we report the first case of a mCRC patient whose disease had progressed on standard lines of treatment and for which we devised a personalized therapeutic approach consisting of vemurafenib (Zelboraf) and panitumumab (Vectibix), based on the following molecular profile: BRAF(V600E)-mutant, amplified EGFR (double positive) and WT KRAS, WT PIK3CA, not-amplified HER2 (triple negative). This new combination therapy was well tolerated and resulted in a strong control of the disease. In particular, the vemurafenib-panitumumab combination appears to limit the typical toxicity of single agents, since no cutaneous toxic effects typically associated with vemurafenib were observed. Here we report the first clinical evidence that the combination of an anti-EGFR (panitumumab) and an inhibitor of BRAF(V600E) (vemurafenib) is well tolerated and results in a strong disease control in an extensively pretreated mCRC patient.

Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer: A case report / Capalbo, Carlo; Marchetti, Paolo; Coppa, Anna; Calogero, Antonella; Anastasi, Emanuela; Buffone, Amelia; Belardinilli, Francesca; Gulino, Matteo; Frati, Paola; Catalano, Carlo; Cortesi, Enrico; Giannini, Giuseppe; Gulino, Alberto. - In: CANCER BIOLOGY & THERAPY. - ISSN 1538-4047. - 15:7(2014), pp. 826-831. [10.4161/cbt.28878]

Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer: A case report

CAPALBO, CARLO;MARCHETTI, PAOLO;COPPA, Anna;CALOGERO, ANTONELLA;ANASTASI, Emanuela;BUFFONE, AMELIA;BELARDINILLI, FRANCESCA;GULINO, MATTEO;FRATI, PAOLA;CATALANO, Carlo;CORTESI, Enrico;GIANNINI, Giuseppe;GULINO, Alberto
2014

Abstract

As the knowledge on cancer genetic alterations progresses, it fosters the need for more personalized therapeutic intervention in modern cancer management. Recently, mutations in KRAS, BRAF, and PIK3CA genes have emerged as important mechanisms of resistance to EGFR-targeted therapy in metastatic colorectal cancer (mCRC). Here we report the first case of a mCRC patient whose disease had progressed on standard lines of treatment and for which we devised a personalized therapeutic approach consisting of vemurafenib (Zelboraf) and panitumumab (Vectibix), based on the following molecular profile: BRAF(V600E)-mutant, amplified EGFR (double positive) and WT KRAS, WT PIK3CA, not-amplified HER2 (triple negative). This new combination therapy was well tolerated and resulted in a strong control of the disease. In particular, the vemurafenib-panitumumab combination appears to limit the typical toxicity of single agents, since no cutaneous toxic effects typically associated with vemurafenib were observed. Here we report the first clinical evidence that the combination of an anti-EGFR (panitumumab) and an inhibitor of BRAF(V600E) (vemurafenib) is well tolerated and results in a strong disease control in an extensively pretreated mCRC patient.
2014
BRAF; Colorectal cancer; Cutaneous toxicity; EGFR; Panitumumab; Personalized medicine; Target therapy; Vemurafenib; Adenocarcinoma; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Humans; Indoles; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf; Sulfonamides; Cancer Research; Oncology; Molecular Medicine; Pharmacology; Medicine (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer: A case report / Capalbo, Carlo; Marchetti, Paolo; Coppa, Anna; Calogero, Antonella; Anastasi, Emanuela; Buffone, Amelia; Belardinilli, Francesca; Gulino, Matteo; Frati, Paola; Catalano, Carlo; Cortesi, Enrico; Giannini, Giuseppe; Gulino, Alberto. - In: CANCER BIOLOGY & THERAPY. - ISSN 1538-4047. - 15:7(2014), pp. 826-831. [10.4161/cbt.28878]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/839845
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