DNA damage transactivates tumour protein p53 (TP53)-regulated surveillance, crucial in suppressing tumorigenesis. TP53 mediates this process directly by transcriptionally modulating gene and microRNA (miRNA) expression and indirectly by regulating miRNA biogenesis. However, the role of TP53 in regulating miRNA-AGO2 loading and global changes in AGO2 binding to its gene targets in response to DNA damage are unknown. These processes might be novel mechanisms by which TP53 regulates miRNAs in response to DNA damage.
The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network / Krell, J; Stebbing, J; Frampton, Ae; Carissimi, Claudia; Harding, V; De Giorgio, A; Fulci, Valerio; Macino, Giuseppe; Colombo, Teresa; Castellano, L.. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 385 Suppl 1:(2015), pp. S15-S15. (Intervento presentato al convegno Spring Meeting for Clinician Scientists in Training 2015 tenutosi a ...) [10.1016/S0140-6736(15)60330-0].
The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network
CARISSIMI, Claudia;FULCI, Valerio;MACINO, Giuseppe;COLOMBO, TERESA;
2015
Abstract
DNA damage transactivates tumour protein p53 (TP53)-regulated surveillance, crucial in suppressing tumorigenesis. TP53 mediates this process directly by transcriptionally modulating gene and microRNA (miRNA) expression and indirectly by regulating miRNA biogenesis. However, the role of TP53 in regulating miRNA-AGO2 loading and global changes in AGO2 binding to its gene targets in response to DNA damage are unknown. These processes might be novel mechanisms by which TP53 regulates miRNAs in response to DNA damage.| File | Dimensione | Formato | |
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