Lactoferrin is a glycoprotein and plays an important role in defence against pathogens. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. The effect of lactoferrin on echovirus 6 infection in vitro was analysed and results showed that (i) cells infected with echovirus 6, died as a result of apoptosis and that (ii) programmed cell death was inhibited by lactoferrin treatment. In this report, we demonstrate that lactoferrin can exert its anti-enteroviral activity by preventing viral-induced apoptosis. (C) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Inhibitory activity of bovine lactoferrin against echovirus induced programmed cell death in vitro / Antonella, Tinari; Agostina, Pietrantoni; Maria Grazia, Ammendolia; Valenti, Piera; Fabiana, Superti. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 25:5(2005), pp. 433-438. [10.1016/j.ijantimicag.2005.02.011]
Inhibitory activity of bovine lactoferrin against echovirus induced programmed cell death in vitro
VALENTI, PIERA;
2005
Abstract
Lactoferrin is a glycoprotein and plays an important role in defence against pathogens. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. The effect of lactoferrin on echovirus 6 infection in vitro was analysed and results showed that (i) cells infected with echovirus 6, died as a result of apoptosis and that (ii) programmed cell death was inhibited by lactoferrin treatment. In this report, we demonstrate that lactoferrin can exert its anti-enteroviral activity by preventing viral-induced apoptosis. (C) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
