Epithelial-to-mesenchymal transition (EMT) consists of a rapid and reversible change in the cellular phenotype toward the mesenchymal cell phenotype that facilitates cell migration and invasion of the tumor into surrounding tissues followed by metastasis. In the present study, we sought to determine the clinical significance of E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin in a cohort of patients with stage I to IVA laryngeal squamous cell carcinoma (LSCC) treated with surgery with or without adjuvant therapy using immunohistochemical analyses.

The prognostic role of E-cadherin and β-catenin overexpression in laryngeal squamous cell carcinoma / Greco, Antonio; De Virgilio, Armando; Rizzo, Maria Ida; Pandolfi, Fabio; Rosati, Davide; De Vincentiis, Marco. - In: LARYNGOSCOPE. - ISSN 0023-852X. - 126:4(2016), pp. e148-e155. [10.1002/lary.25736]

The prognostic role of E-cadherin and β-catenin overexpression in laryngeal squamous cell carcinoma

GRECO, Antonio
Primo
;
DE VIRGILIO, ARMANDO
Secondo
;
RIZZO, MARIA IDA;PANDOLFI, FABIO;ROSATI, DAVIDE
Penultimo
;
DE VINCENTIIS, Marco
Ultimo
2016

Abstract

Epithelial-to-mesenchymal transition (EMT) consists of a rapid and reversible change in the cellular phenotype toward the mesenchymal cell phenotype that facilitates cell migration and invasion of the tumor into surrounding tissues followed by metastasis. In the present study, we sought to determine the clinical significance of E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin in a cohort of patients with stage I to IVA laryngeal squamous cell carcinoma (LSCC) treated with surgery with or without adjuvant therapy using immunohistochemical analyses.
2016
E-cadherin; caveolin-1; epithelial-to-mesenchymal transition; larynx carcinoma; β-catenin
01 Pubblicazione su rivista::01a Articolo in rivista
The prognostic role of E-cadherin and β-catenin overexpression in laryngeal squamous cell carcinoma / Greco, Antonio; De Virgilio, Armando; Rizzo, Maria Ida; Pandolfi, Fabio; Rosati, Davide; De Vincentiis, Marco. - In: LARYNGOSCOPE. - ISSN 0023-852X. - 126:4(2016), pp. e148-e155. [10.1002/lary.25736]
File allegati a questo prodotto
File Dimensione Formato  
Greco_Prognostic_2016.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 464.1 kB
Formato Adobe PDF
464.1 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/835318
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 24
social impact