An anti-I-Ek alloantiserum was shown to react with purified human Ia preparation. All Ia preparations tested were actively bound irrespective of their HLA-DR phenotypes. However, from a quantitative point of view, DR7 molecules were significantly less reactive. No reaction was observed with isolated Ia subunits. Only molecules carrying DR determinants, but not those carrying either DC1 or BR4X7 determinants, were bound.
Human Ia molecules carrying DC1 or BR4x7 determinants are not homologous to murine I-E molecules / Tosi, R; Tanigaki, N; Sorrentino, Rosa; VAN MOURIK, P; Ivany, P.. - In: IMMUNOGENETICS. - ISSN 0093-7711. - 16:(1982), pp. 187-200.
Human Ia molecules carrying DC1 or BR4x7 determinants are not homologous to murine I-E molecules
SORRENTINO, Rosa;
1982
Abstract
An anti-I-Ek alloantiserum was shown to react with purified human Ia preparation. All Ia preparations tested were actively bound irrespective of their HLA-DR phenotypes. However, from a quantitative point of view, DR7 molecules were significantly less reactive. No reaction was observed with isolated Ia subunits. Only molecules carrying DR determinants, but not those carrying either DC1 or BR4X7 determinants, were bound.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
