We design an all-DNA system that behaves like vitrimers, innovative plastics with self-healing andstress-releasing properties. The DNA sequences are engineered to self-assemble first into tetra- andbifunctional units which, upon further cooling, bind to each other forming a fully bonded network gel. Aninnovative design of the binding regions of the DNA sequences, exploiting a double toehold-mediatedstrand displacement, generates a network gel which is able to reshuffle its bonds, retaining at all times fullbonding. As in vitrimers, the rate of bond switching can be controlled via a thermally activated catalyst,which in the present design is very short DNA strands
Switching Bonds in a DNA Gel: An All-DNA Vitrimer / Sciortino, Francesco; Romano, Flavio. - In: PHYSICAL REVIEW LETTERS. - ISSN 0031-9007. - 114:7(2015), p. 078104. [10.1103/PhysRevLett.114.078104]
Switching Bonds in a DNA Gel: An All-DNA Vitrimer
SCIORTINO, Francesco;ROMANO, FLAVIO
2015
Abstract
We design an all-DNA system that behaves like vitrimers, innovative plastics with self-healing andstress-releasing properties. The DNA sequences are engineered to self-assemble first into tetra- andbifunctional units which, upon further cooling, bind to each other forming a fully bonded network gel. Aninnovative design of the binding regions of the DNA sequences, exploiting a double toehold-mediatedstrand displacement, generates a network gel which is able to reshuffle its bonds, retaining at all times fullbonding. As in vitrimers, the rate of bond switching can be controlled via a thermally activated catalyst,which in the present design is very short DNA strandsFile | Dimensione | Formato | |
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