Are there differences among anti-TNFalpha biological drugs?

OBJECTIVE: To provide an analysis and a guide tool in using TNFα-antagonists in the current clinical practice. METHODS: Review of the literature on the differences among the three TNFα-antagonists in terms of molecular structure, mechanism of action, pharmacokinetics, effects on the immune and neuroendocrine systems, and therapeutic indications. RESULTS AND CONCLUSIONS: Unfortunately, results of direct comparison studies are lacking. One could obviate this problem by performing statistical-mathematical extrapolations, but there are very few and very small-sized published experimental evidences.