BACKGROUND/AIM: Aim of the present study was to assess the diagnostic value of unenhanced biparametric magnetic resonance imaging (Bp-MRI) as adjunct to CA125 and human epididymis protein 4 (HE4) in the characterization of large ovarian masses. PATIENTS AND METHODS: Bp-MRI and dynamic contrast-enhanced (DCE) imaging of 53 patients with large ovarian masses were retrospectively analyzed and compared to histological diagnosis. The results of Bp-MRI and DCE were assessed by two readers in consensus for each technique individually compared to each other and then with HE4 and CA125. RESULTS: Sensitivity, specificity, negative predictive values and positive predictive values for Bp-MRI and DCE were 92.3%, 91.4%, 94.1%, 88.9% and 84.6%, 94.3%, 89.2%, 91.7%, respectively. Both Bp-MRI and DCE were significant predictors of outcome. Among biomarkers, HE4 was significant. Considering the area under receiver operating characteristic curve the model including Bp-MRI and HE4 was not significantly different from the model including DCE and HE4. CONCLUSION: Bp-MRI in addition to HE4, especially in women of pre-menopausal age, could improve the characterization of large ovarian masses. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Biparametric magnetic resonance imaging as an adjunct to CA125 and HE4 to improve characterization of large ovarian masses / Manganaro, Lucia; Anastasi, Emanuela; Porpora, Maria Grazia; Vinci, Valeria; Saldari, Matteo; Bernardo, Silvia; Ballesio, Laura; Sollazzo, Paolo; Pecorella, Irene; Recchia, N; Stracci, F; BENEDETTI PANICI, Pierluigi; Angeloni, Antonio; Catalano, Carlo; Scialpi, M. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 35:11(2015), pp. 6341-6351.

Biparametric magnetic resonance imaging as an adjunct to CA125 and HE4 to improve characterization of large ovarian masses

MANGANARO, Lucia
Primo
;
ANASTASI, Emanuela
Secondo
;
PORPORA, Maria Grazia;VINCI , VALERIA;SALDARI, MATTEO;BERNARDO, SILVIA;BALLESIO, Laura;SOLLAZZO, PAOLO;PECORELLA, Irene;BENEDETTI PANICI, PIERLUIGI;ANGELONI, Antonio;CATALANO, Carlo
Penultimo
;
2015

Abstract

BACKGROUND/AIM: Aim of the present study was to assess the diagnostic value of unenhanced biparametric magnetic resonance imaging (Bp-MRI) as adjunct to CA125 and human epididymis protein 4 (HE4) in the characterization of large ovarian masses. PATIENTS AND METHODS: Bp-MRI and dynamic contrast-enhanced (DCE) imaging of 53 patients with large ovarian masses were retrospectively analyzed and compared to histological diagnosis. The results of Bp-MRI and DCE were assessed by two readers in consensus for each technique individually compared to each other and then with HE4 and CA125. RESULTS: Sensitivity, specificity, negative predictive values and positive predictive values for Bp-MRI and DCE were 92.3%, 91.4%, 94.1%, 88.9% and 84.6%, 94.3%, 89.2%, 91.7%, respectively. Both Bp-MRI and DCE were significant predictors of outcome. Among biomarkers, HE4 was significant. Considering the area under receiver operating characteristic curve the model including Bp-MRI and HE4 was not significantly different from the model including DCE and HE4. CONCLUSION: Bp-MRI in addition to HE4, especially in women of pre-menopausal age, could improve the characterization of large ovarian masses. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/825457
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