Objective: To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. Patients and Methods: A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors. Results: Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of >= 1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls. Conclusion: Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.

OBJECTIVE: To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. PATIENTS AND METHODS: A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors. RESULTS: Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls. CONCLUSION: Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.

Maternal thrombophilia and adverse pregnancy outcome: a case-control study / Mazzucconi, Maria Gabriella; DE SANCTIS, Vitaliana; Alfo', Marco; Amendolea, Maria Antonietta; Conti, Laura; Santoro, Cristina; Erminia, Baldacci; Monica, Peraino; Cesare, Masala. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 133:2(2015), pp. 242-248. [10.1159/000363048]

Maternal thrombophilia and adverse pregnancy outcome: a case-control study

MAZZUCCONI, Maria Gabriella;DE SANCTIS, Vitaliana;ALFO', Marco;AMENDOLEA, Maria Antonietta;CONTI, Laura;SANTORO, Cristina;
2015

Abstract

Objective: To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. Patients and Methods: A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors. Results: Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of >= 1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls. Conclusion: Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.
2015
OBJECTIVE: To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. PATIENTS AND METHODS: A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors. RESULTS: Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls. CONCLUSION: Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.
Miscarriage; Thrombophilia; Pregnancy, factorv-Leiden; definite antiphospholypid syndrome; international consensus statement; silica clotting time; viper venom time; recurrent miscarriage; classification criteria; lupus; anti coagulants; women
01 Pubblicazione su rivista::01a Articolo in rivista
Maternal thrombophilia and adverse pregnancy outcome: a case-control study / Mazzucconi, Maria Gabriella; DE SANCTIS, Vitaliana; Alfo', Marco; Amendolea, Maria Antonietta; Conti, Laura; Santoro, Cristina; Erminia, Baldacci; Monica, Peraino; Cesare, Masala. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 133:2(2015), pp. 242-248. [10.1159/000363048]
File allegati a questo prodotto
File Dimensione Formato  
Mazzucconi_ Maternal Thrombophilia _2014.pdf

solo gestori archivio

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 138.72 kB
Formato Adobe PDF
138.72 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/824035
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 4
social impact