Ocular burns cause depletion of limbal stem cells, which leads to corneal opacification and visual loss. Autologous cultured epithelial cells can restore damaged corneas, but this technology is still developing. We sought to establish a culture system that allows preservation of limbal stem cells and preparation of manageable epithelial sheets and to investigate whether such cultures can permanently restore total limbal stem cell deficiency.

Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency / Rama, P; Bonini, S; Lambiase, Alessandro; Golisano, O; Paterna, P; De Luca, M; Pellegrini, G.. - In: TRANSPLANTATION. - ISSN 0041-1337. - STAMPA. - 72:9(2001), pp. 1478-1485.

Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency

LAMBIASE, ALESSANDRO;
2001

Abstract

Ocular burns cause depletion of limbal stem cells, which leads to corneal opacification and visual loss. Autologous cultured epithelial cells can restore damaged corneas, but this technology is still developing. We sought to establish a culture system that allows preservation of limbal stem cells and preparation of manageable epithelial sheets and to investigate whether such cultures can permanently restore total limbal stem cell deficiency.
2001
3T3 Cells; Adult; Animals; Cell Culture Techniques; Cells, Cultured; Cornea; Corneal Transplantation; Eye Burns; Female; Fibrin; Functional Laterality; Humans; Keratinocytes; Limbus Corneae; Male; Mice; Middle Aged; Transplantation, Autologous; Hematopoietic Stem Cell Transplantation
01 Pubblicazione su rivista::01a Articolo in rivista
Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency / Rama, P; Bonini, S; Lambiase, Alessandro; Golisano, O; Paterna, P; De Luca, M; Pellegrini, G.. - In: TRANSPLANTATION. - ISSN 0041-1337. - STAMPA. - 72:9(2001), pp. 1478-1485.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/822303
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