In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity.
CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA / Bracci Laudiero, Luisa; Starace, Giuseppe; Antonelli, Alessia; Lambiase, Alessandro; Procoli, Annabella; Rumi, Carlo; Lai, Marco; Picardi, Alessandra; Ballatore, Giovanna; Bonini, Sergio; Aloe, Luigi; Celestino, Domenico. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 136:1-2(2003), pp. 130-139.
CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA
LAMBIASE, ALESSANDRO;CELESTINO, Domenico
2003
Abstract
In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
