Nerve growth factor (NGF) has been shown to inhibit retinal ganglion cell (RGC) degeneration when injected intraocularly in animal models of ocular hypertension, optic nerve transaction, and ischemia. The present study sought to establish the bioavailability of topical NGF to the retina and optic nerve in rats.
Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats / Lambiase, Alessandro; Tirassa, Paola; Micera, Alessandra; Aloe, Luigi; Bonini, Stefano. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - STAMPA. - 46:10(2005), pp. 3800-3806. [10.1167/iovs.05-0301]
Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult rats
LAMBIASE, ALESSANDRO;
2005
Abstract
Nerve growth factor (NGF) has been shown to inhibit retinal ganglion cell (RGC) degeneration when injected intraocularly in animal models of ocular hypertension, optic nerve transaction, and ischemia. The present study sought to establish the bioavailability of topical NGF to the retina and optic nerve in rats.File allegati a questo prodotto
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