Glial cells and fibroblasts (FBs) play a key role in epiretinal membrane (ERM) development and progression. Myofibroblasts (myoFBs), arising from these cells, can lead to the hypertrophic scars and tissue contraction observed in ERMs. Nerve growth factor (NGF) and transforming growth factor-beta1 (TGF-beta1) play a crucial role in FB activities. Therefore, the authors evaluated myoFBs in ERMs and NGF, trkA(NGFR and p75(NTR) expression, as well as TGF-beta1/TGF-betaRII levels in both ERMs and vitreous.

Human idiopathic epiretinal membranes express NGF and NGF receptors / Minchiotti, Simona; Stampachiacchiere, Barbara; Micera, Alessandra; Lambiase, Alessandro; Ripandelli, Guido; Billi, Bernardo; Bonini, Stefano. - In: RETINA. - ISSN 0275-004X. - STAMPA. - 28:4(2008), pp. 628-637. [10.1097/IAE.0b013e31815ec275]

Human idiopathic epiretinal membranes express NGF and NGF receptors

LAMBIASE, ALESSANDRO;
2008

Abstract

Glial cells and fibroblasts (FBs) play a key role in epiretinal membrane (ERM) development and progression. Myofibroblasts (myoFBs), arising from these cells, can lead to the hypertrophic scars and tissue contraction observed in ERMs. Nerve growth factor (NGF) and transforming growth factor-beta1 (TGF-beta1) play a crucial role in FB activities. Therefore, the authors evaluated myoFBs in ERMs and NGF, trkA(NGFR and p75(NTR) expression, as well as TGF-beta1/TGF-betaRII levels in both ERMs and vitreous.
2008
Actins; Adult; Aged; Aged, 80 and over; Enzyme-Linked Immunosorbent Assay; Epiretinal Membrane; Female; Fibroblasts; Fluorescent Antibody Technique, Indirect; Humans; Male; Middle Aged; Nerve Growth Factor; Nerve Tissue Proteins; Protein-Serine-Threonine Kinases; RNA, Messenger; Receptor, trkA; Receptors, Nerve Growth Factor; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1; Vitreous Body
01 Pubblicazione su rivista::01a Articolo in rivista
Human idiopathic epiretinal membranes express NGF and NGF receptors / Minchiotti, Simona; Stampachiacchiere, Barbara; Micera, Alessandra; Lambiase, Alessandro; Ripandelli, Guido; Billi, Bernardo; Bonini, Stefano. - In: RETINA. - ISSN 0275-004X. - STAMPA. - 28:4(2008), pp. 628-637. [10.1097/IAE.0b013e31815ec275]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/822268
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