The administration of neurotrophins has been clearly demonstrated to support survival of retina cells during a variety of insults. Increased levels of neurotrophins, such as the nerve growth factor (NGF), have been found in experimental models of glaucoma. Nevertheless, loss of retinal cells does occur in the course of ocular hypertension. Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma.

Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma / Coassin, Marco; Lambiase, Alessandro; Sposato, Valentina; Micera, Alessandra; Bonini, Stefano; Aloe, Luigi. - In: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. - ISSN 1435-702X. - STAMPA. - 246:12(2008), pp. 1743-1749. [10.1007/s00417-008-0913-5]

Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma

LAMBIASE, ALESSANDRO;
2008

Abstract

The administration of neurotrophins has been clearly demonstrated to support survival of retina cells during a variety of insults. Increased levels of neurotrophins, such as the nerve growth factor (NGF), have been found in experimental models of glaucoma. Nevertheless, loss of retinal cells does occur in the course of ocular hypertension. Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma.
2008
Animals; Cell Count; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Nerve Growth Factor; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Rats; Rats, Inbred BN; Receptor, trkA; Receptors, Nerve Growth Factor; Retina; Time Factors; Up-Regulation; bcl-2-Associated X Protein; Apoptosis; Retinal Ganglion Cells
01 Pubblicazione su rivista::01a Articolo in rivista
Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma / Coassin, Marco; Lambiase, Alessandro; Sposato, Valentina; Micera, Alessandra; Bonini, Stefano; Aloe, Luigi. - In: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. - ISSN 1435-702X. - STAMPA. - 246:12(2008), pp. 1743-1749. [10.1007/s00417-008-0913-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/822267
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