In vitro and in vivo studies demonstrated the antiviral efficacy of nerve growth factor (NGF) and its cyto-protective effect in herpes simplex virus (HSV)-infected cells. The aims of this study were to evaluate the role of endogenous NGF in HSV corneal infection, and the effects of topical NGF treatment on herpetic keratitis.

Topical treatment with nerve growth factor in an animal model of herpetic keratitis / Lambiase, Alessandro; Coassin, Marco; Costa, Nicola; Lauretti, Paolo; Micera, Alessandra; Ghinelli, Emiliano; Aloe, Luigi; Rama, Paolo; Bonini, Stefano. - In: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. - ISSN 1435-702X. - STAMPA. - 246:1(2008), pp. 121-127. [10.1007/s00417-007-0593-6]

Topical treatment with nerve growth factor in an animal model of herpetic keratitis

LAMBIASE, ALESSANDRO;
2008

Abstract

In vitro and in vivo studies demonstrated the antiviral efficacy of nerve growth factor (NGF) and its cyto-protective effect in herpes simplex virus (HSV)-infected cells. The aims of this study were to evaluate the role of endogenous NGF in HSV corneal infection, and the effects of topical NGF treatment on herpetic keratitis.
2008
Acyclovir; Administration, Topical; Animals; Antibodies, Blocking; Antiviral Agents; Cytoprotection; Female; Herpesvirus 1, Human; Immunoenzyme Techniques; Keratitis, Herpetic; Nerve Growth Factor; Polymerase Chain Reaction; Prospective Studies; Rabbits; Viral Envelope Proteins; Virus Replication; Disease Models, Animal
01 Pubblicazione su rivista::01a Articolo in rivista
Topical treatment with nerve growth factor in an animal model of herpetic keratitis / Lambiase, Alessandro; Coassin, Marco; Costa, Nicola; Lauretti, Paolo; Micera, Alessandra; Ghinelli, Emiliano; Aloe, Luigi; Rama, Paolo; Bonini, Stefano. - In: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. - ISSN 1435-702X. - STAMPA. - 246:1(2008), pp. 121-127. [10.1007/s00417-007-0593-6]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/822264
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 17
social impact