Matrix metalloproteinases (MMPs) have a role in the pathogenesis of rosacea-associated chronic blepharitis. Doxycycline is largely used as a treatment for recalcitrant chronic blepharitis. It has been shown in vitro that doxycycline inhibits MMPs activation. The aim of this study was to investigate in vivo the effect of doxycycline in modulating MMPs in patients with chronic idiopathic blepharitis.
In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis / Iovieno, Alfonso; Lambiase, Alessandro; Micera, Alessandra; Stampachiacchiere, Barbara; Sgrulletta, Roberto; Bonini, Stefano. - In: EUROPEAN JOURNAL OF OPHTHALMOLOGY. - ISSN 1120-6721. - STAMPA. - 19:5(2009), pp. 708-716.
In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis
LAMBIASE, ALESSANDRO;
2009
Abstract
Matrix metalloproteinases (MMPs) have a role in the pathogenesis of rosacea-associated chronic blepharitis. Doxycycline is largely used as a treatment for recalcitrant chronic blepharitis. It has been shown in vitro that doxycycline inhibits MMPs activation. The aim of this study was to investigate in vivo the effect of doxycycline in modulating MMPs in patients with chronic idiopathic blepharitis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
