Keratoconus is the most commoncorneal dystrophy that leads to severe visual impairment. Although the major etiological factors are genetic, the pathogenetic mechanism(s) is unknown. Previous studies demonstrated an increased apoptosis of corneal cells, a decreased corneal sensitivity, anatomic corneal nerve changes and a progression of the disease after trigeminal nerve injury, suggesting a pathogenic role of corneal sensorial innervation in keratoconus development and progression. Corneal nerves release several neuromediators, including substance P (SP), calcitonin-gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) that modulate corneal trophism, healing and inflammation.
Preliminary evidence of neuropeptides involvement in keratoconus / Sacchetti, Marta; Scorcia, Vincenzo; Lambiase, Alessandro; Bonini, Stefano. - In: ACTA OPHTHALMOLOGICA. - ISSN 1755-3768. - STAMPA. - 93:4(2015), pp. 315-316. [10.1111/aos.12483]
Preliminary evidence of neuropeptides involvement in keratoconus
SACCHETTI, MARTAPrimo
;LAMBIASE, ALESSANDRO
;
2015
Abstract
Keratoconus is the most commoncorneal dystrophy that leads to severe visual impairment. Although the major etiological factors are genetic, the pathogenetic mechanism(s) is unknown. Previous studies demonstrated an increased apoptosis of corneal cells, a decreased corneal sensitivity, anatomic corneal nerve changes and a progression of the disease after trigeminal nerve injury, suggesting a pathogenic role of corneal sensorial innervation in keratoconus development and progression. Corneal nerves release several neuromediators, including substance P (SP), calcitonin-gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) that modulate corneal trophism, healing and inflammation.File | Dimensione | Formato | |
---|---|---|---|
Sacchetti_Preliminary evidence_2015.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
230.96 kB
Formato
Adobe PDF
|
230.96 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.