Bloch surface waves (BSW) propagating at the boundary of truncated photonic crystals (1D-PC) have emerged as an attractive approach for label-free sensing in plasmon-like sensor configurations. Due to the very low losses in such dielectric thin film stacks, BSW feature very low angular resonance widths compared to the surface plasmon resonance (SPR) case. Besides label-free operation, the large field enhancement and the absence of quenching allow utilizing BSW coupled fluorescence detection to additionally sense the presence of fluorescent labels. This approach can be adapted to the case of angularly resolved resonance detection, thus giving rise to a combined label-free / labelled biosensor platform. It features a parallel analysis of multiple spots arranged as a one-dimensional array inside a microfluidic channel of a disposable chip. Application of such a combined biosensing approach to the detection of the Angiopoietin-2 cancer biomarker in buffer solutions is reported.

Biosensing platform combining label-free and labelled analysis using Bloch surface waves / Danz, Norbert; Sinibaldi, Alberto; Munzert, Peter; Anopchenko, Oleksiy; Förster, Erik; Schmieder, Stefan; Chandrawati, Rona; Rizzo, Riccardo; Heller, Rene; Sonntag, Frank; Mascioletti, Alessandro; Rana, Subinoy; Schubert, Thomas; Stevens, Molly M.; Michelotti, Francesco. - STAMPA. - 9506:(2015), p. 95060V. ((Intervento presentato al convegno SPIE Optics + Optoelectronics tenutosi a Praha, Czech Republik nel 2015 [10.1117/12.2178444].

Biosensing platform combining label-free and labelled analysis using Bloch surface waves

SINIBALDI, ALBERTO;ANOPCHENKO, OLEKSIY;RIZZO, Riccardo;MICHELOTTI, Francesco
2015

Abstract

Bloch surface waves (BSW) propagating at the boundary of truncated photonic crystals (1D-PC) have emerged as an attractive approach for label-free sensing in plasmon-like sensor configurations. Due to the very low losses in such dielectric thin film stacks, BSW feature very low angular resonance widths compared to the surface plasmon resonance (SPR) case. Besides label-free operation, the large field enhancement and the absence of quenching allow utilizing BSW coupled fluorescence detection to additionally sense the presence of fluorescent labels. This approach can be adapted to the case of angularly resolved resonance detection, thus giving rise to a combined label-free / labelled biosensor platform. It features a parallel analysis of multiple spots arranged as a one-dimensional array inside a microfluidic channel of a disposable chip. Application of such a combined biosensing approach to the detection of the Angiopoietin-2 cancer biomarker in buffer solutions is reported.
SPIE Optics + Optoelectronics
Bloch surface waves; fluorescence and luminescence; label-free optical sensors; optical biosensors; optical multilayer systems; photonic crystal; Applied Mathematics; Computer Science Applications1707 Computer Vision and Pattern Recognition; Electrical and Electronic Engineering; Electronic, Optical and Magnetic Materials; Condensed Matter Physics
04 Pubblicazione in atti di convegno::04b Atto di convegno in volume
Biosensing platform combining label-free and labelled analysis using Bloch surface waves / Danz, Norbert; Sinibaldi, Alberto; Munzert, Peter; Anopchenko, Oleksiy; Förster, Erik; Schmieder, Stefan; Chandrawati, Rona; Rizzo, Riccardo; Heller, Rene; Sonntag, Frank; Mascioletti, Alessandro; Rana, Subinoy; Schubert, Thomas; Stevens, Molly M.; Michelotti, Francesco. - STAMPA. - 9506:(2015), p. 95060V. ((Intervento presentato al convegno SPIE Optics + Optoelectronics tenutosi a Praha, Czech Republik nel 2015 [10.1117/12.2178444].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/817259
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